نتایج جستجو برای: پروتئین ns3

تعداد نتایج: 20586  

Journal: :PloS one 2016
Monika Simmons Peifang Sun Robert Putnak

Dengue virus purified inactivated vaccines (PIV) are highly immunogenic and protective over the short term, but may be poor at inducing cell-mediated immune responses and long-term protection. The dengue nonstructural protein 3 (NS3) is considered the main target for T-cell responses during viral infection. The amino (N)-terminal protease and the carboxy (C)-terminal helicase domains of DENV-2 ...

2015
Fengqin Zhu Tian Chen Yeqiong Zhang Haixia Sun Hong Cao Jianxi Lu Linshan Zhao Gang Li R. Jude Samulski

More than 170 million individuals worldwide are infected with hepatitis C virus (HCV), and up to an estimated 30% of chronically infected individuals will go on to develop progressive liver disease. Despite the recent advances in antiviral treatment of HCV infection, it remains a major public health problem. Thus, development of an effective vaccine is urgently required. In this study, we const...

Journal: :CoRR 2017
Marc Mosko Ramesh Ayyagari Priti Goel Eric Holmberg Mark Konezny

The ccns3Sim project is an open source implementation of the CCNx 1.0 protocols for the NS3 [2] simulator. We describe the implementation and several important features including modularity and process delay simulation. The ccns3Sim implementation is a fresh NS3-specific implementation. Like NS3 itself, it uses C++98 standard, NS3 code style, NS3 smart pointers, NS3 xUnit, and integrates with t...

Journal: :Antiviral research 2012
Jean Ndjomou Rajesh Kolli Sourav Mukherjee William R Shadrick Alicia M Hanson Noreena L Sweeney Diana Bartczak Kelin Li Kevin J Frankowski Frank J Schoenen David N Frick

The hepatitis C virus (HCV) multifunctional nonstructural protein 3 (NS3) is a protease that cleaves viral and host proteins and a helicase that separates DNA and RNA structures in reactions fueled by ATP hydrolysis. Li et al. (2012) recently synthesized a series of new NS3 helicase inhibitors from the benzothiazole dimer component of the fluorescent yellow dye primuline. This study further cha...

2017
Raghavendra Sumanth Pudupakam Shobana Raghunath Meghanath Pudupakam Sreenivasulu Daggupati

AIM Sequence analysis and phylogenetic studies based on non-structural protein-3 (NS3) gene are important in understanding the evolution and epidemiology of bluetongue virus (BTV). This study was aimed at characterizing the NS3 gene sequence of Indian BTV serotype-2 (BTV2) to elucidate its genetic relationship to global BTV isolates. MATERIALS AND METHODS The NS3 gene of BTV2 was amplified fr...

Journal: :F1000Research 2022

Background: This study aims to determine the factors affecting HBV DNA suppression in chronic hepatitis B patients with tenofovir disoproxil fumarate (TDF). Methods: A case-control was carried out from October 2021 August 2022 on 182 who had TDF therapy regularly for 24 weeks at H. Adam Malik and USU Hospitals Medan, Indonesia. The...

Journal: :F1000Research 2022

Background: Human Givens (HG) Rewind is a relatively unknown trauma-focussed treatment. This paper aimed to provide preliminary evidence of the effectiveness treat posttraumatic stress (PTS) in variety clinical settings Great Britain. Methods: An observational prospective design was used each four studies. Standardised questionnair...

Journal: :F1000Research 2023

Background: Sleeping sickness is caused by the extracellular parasite Trypanosoma brucei and associated with neuroinflammation neuropsychiatric disorders, including disruption of sleep/wake patterns, now recognised as a circadian disorder. traditionally studied using murine models infection due to lack alternative in vitro</ns3:it...

Journal: :F1000Research 2022

Background Changes in blood transcript abundance levels have been associated with pathogenesis a wide range of diseases. While next generation sequencing technology can measure on genome-wide scale, downstream clinical applications often require small sets genes to be selected for inclusion targeted panels. Here we set out gather information from the l...

Journal: :F1000Research 2023

Background: The aim of this study was to perform a comparative evaluation 5% Sodium fluoride varnish, neutral nano silver (NSF) varnish and acidulated in remineralising artificially induced enamel caries primary teeth. Methods: 39 anterior teeth were sectioned 2mm below the cemento-enamel junction (CEJ) mounted acrylic resin blocks...

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