پاروویروس 19b

1 State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an, Shaanxi, 710032,China 2 Ningxia Medical University Affiliated Hospital, Yinchuan, Ningxia, 750004, China. 3 These authors contributed equally to this work. Correspondence State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military M...

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MicroRNA miR-92a-1 biogenesis and mRNA targeting is modulated by a tertiary contact within the miR-17∼92 microRNA cluster

2014

Steven G. Chaulk Zhizhong Xu Mark J. N. Glover Richard P. Fahlman

While functional mature microRNAs (miRNAs) are small ∼22 base oligonucleotides that target specific mRNAs, miRNAs are initially expressed as long transcripts (pri-miRNAs) that undergo sequential processing to yield the mature miRNAs. We have previously reported that the pri-miR-17∼92 cluster adopts a compact globular folded structure that internalizes a 3' core domain resulting in reduced miRNA...

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