background: vitamin b12 (cobalamin) deficiency can result in some clinical and paraclinical characteristics similar to what is seen in multiple sclerosis (ms) patients. this study aimed to evaluate the controversial association between vitamin b12 deficiency and ms. methods: we measured serum vitamin b12 in 60 patients with ms and 38 healthy controls. clinical disability was evaluated according...

The overwhelming consensus in the mainstream nutrition community, as well as among vegan health professionals, is that plant foods do not provide vitamin B12. Despite this, some vegan advocates still believe that plant foods provide all the nutrients necessary for optimal health and, therefore, do not address vitamin B12 when promoting the vegan diet. Other vegan advocates acknowledge the need ...

In this contribution we investigated the correlation between plasma vitamin B12 levels and cognitive impairment in Alzheimer's disease. We could demonstrate a significant inverse correlation when the MMSE scores of those patients with the lowest 10% Vitamin B12 plasma levels (<184 ng/ml) were compared with the upper 10% Vitamin B12 plasma levels (>598 ng/ml): p=0.008, Spearman-Rho= -0.36. MMSE ...

I N PREVIOUS REPORTS’3 it was shown that uncoated charcoal adsorbs both free vitamin B12 and B12 bound to proteins, but charcoal precoated by mixing with saturating quantities of albumin adsorbs only free B12. This finding has been confirmed.4 The charcoal particles may be considered as solid microsponges and the albumin coat as a molecular sieve surrounding each sponge. Small molecules such as...

Bg CHESTER GorruEB, KAM-SENG LAU, Louis R. \VASSERMAN AND VICTOR HERBERT T HIS COMMUNICATION reports the use of protein-coated charcoal iii rapid assays for: (1) intrinsic factor (IF), (2) unsaturated B12 binding capacity of gastric juice, (3) antibody to IF, and (4) serum unsaturated B12 binding capacity. The assays are based on the finding that charcoal precoated with a large molecule can ads...

Long-term usage of antiepileptic drugs (AED) may lead to changes in serum vitamin B12 (B12) levels. Studies show that after sodium valproate prescription in epileptic patients, B12 concentrations increased.1 On the other hand, in the normal population, serum levels of B12 decreases with age.2 In the case of B12 deficiency, various hematologic, neurologic, and psychiatric clinical findings may b...

OBJECTIVES This study aims to assess the usefulness of serum holotranscobalamin (holoTC), the fraction of vitamin B12 that is available for tissue uptake, compared with total vitamin B12 in patients investigated for vitamin B12 disorders. METHODS Serum samples were randomly selected from 76 patients (48 females, 28 males; age range 12-69 years) referred to the Clinical Biochemistry Laboratory...

BACKGROUND Profound vitamin B12 deficiency is a known cause of disease, but the role of low or intermediate levels of B12 in the development of neuropathy and other neuropsychiatric symptoms, as well as the relationship between eating meat and B12 levels, is unclear. OBJECTIVE The objective of our study was to investigate the role of low or intermediate levels of B12 in the development of neu...

Several observations suggest that the absorption of vitamin B12 may be inhibited by bacteria. Both in experimental animals and in patients with blind loops, strictures, or fistulae involving the small intestine, heavy growths of bacteria have been found in areas of the bowel which are normally sterile (Seyderhelm, Lehmann, and Wichels, 1924; Doig and Girdwood, 1960). In patients with such lesio...

I N THE PAST SEVERAL YEARS a number of radioassay procedures for serum vitamin B12 have been described. Each method is based on the fact that unlabeled crystalline B12 will competitively inhibit isotopically labeled B12 (tracer B12) from binding to a specific B12 binding protein(s). Basic to each procedure is the reaction of B12 (labeled and unlabeled) with a limited quantity of binding protein...