نتایج جستجو برای: واژههای کلیدی agrp
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تاثیر هشت هفته تمرین دایره ای اختصاصی جودو بر مقادیرagrp و شاخص های عملکردی مردان جودوکار تمرین کرده
هدف: هیپو تالاموس به واسطه ترشح نروپپتایدهای مختلف به عنوان مرکز اصلی هموستاز انرژیبه نظر میرسد که یکی از آنان agrp یا پروتئین وابسته به آگوتی باشد. لذا تحقیق حاضر با هدف مقایسه اثر 8 هفته تمرینات دایره ای مبتنی بر فنون جودو و تمرینات عادی جودو بر مقادیر agrp پلاسمای جودوکاران تمرین کرده انجام پذیرفت . روش تحقیق: بدین منظور20 جودوکار تمرین کرده مرد به صورت داوطلباته (میانگین ± انحراف معیار، وزن...
The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor mainly expressed in the central nervous system of vertebrates. Activation of the MC4R leads to a decrease in food intake, whereas inactivating mutations are a genetic cause of obesity. The binding of agouti-related protein (AGRP) reduces not only agonist-stimulated cAMP production (competitive antagonist) but also the basal acti...
Neuropeptide Y (NPY)/Agouti-related peptide (AgRP)-expressing neurons in the hypothalamus induce feeding and decrease energy expenditure. With consumption of a diet high in fat, there is an increase in circulating saturated free fatty acids, including palmitate, leading to the development of neuroinflammation and secretion of cytokines, such as TNFα, and in turn activation of the canonical IKKβ...
Leptin acts via neuronal leptin receptors to control energy balance. Hypothalamic pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP)/Neuropeptide Y (NPY)/GABA neurons produce anorexigenic and orexigenic neuropeptides and neurotransmitters, and express the long signaling form of the leptin receptor (LepRb). Despite progress in the understanding of LepRb signaling and function, the sub...
Anorexigenic melanocortins decrease food intake by activating MC3/MC4 receptors (MC3/4R); the prevailing view is that the orexigenic neuropeptide agouti-related peptide (AgRP) exerts the opposite action by acting as an antagonist at MC3/MC4 receptors. A total of 370 hypothalamic ventromedial nucleus (VMH) glutamatergic neurons was studied using whole-cell recording in hypothalamic slices from a...
Hypothalamic glucose-sensing neurons regulate the expression of genes encoding feeding-related neuropetides POMC, AgRP, and NPY - the key components governing metabolic homeostasis. AMP-activated protein kinase (AMPK) is postulated to be the molecular mediator relaying glucose signals to regulate the expression of these neuropeptides. Whether other signaling mediator(s) plays a role is not clea...
سابقه و هدف:آگوتی وابسته به پروتئین (AgRP) یک پپتید اشتهاآور موثر بر تنظیم و تعادل انرژی است که به طور عمده در هسته‌های کمانی هیپوتالاموس بیان می‌شود. هدف از پژوهش حاضر بررسی تاثیرمصرف فروکتوز بر سطح AgRP، انسولین و گلوکز پلاسما پس از یک جلسه فعالیت هوازی در مردان جوان دانشگاهی بود. مواد و روشها:12دانشجوی مرد غیرورزشکار (سن 37/1±33/21 سال ، وزن 89/8±25/74 کیلوگرم، قد 05/0±76/1متر و شاخص توده ب...
The activity of the ubiquitin proteasome system (UPS) is downregulated in aggregation diseases such as Alzheimer's disease (AD). In this study, we investigated the therapeutic potential of the Agouti-related peptide (AgRP), which is secreted by human mesenchymal stem cells (MSCs), in terms of its effect on the regulation of proteasome activity in AD. When SH-SY5Y human neuroblastoma cells were ...
Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy homeostasis. Here, we provide evidence that AGRP inhibitory tone to iBAT represents an energy-sparin...
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