BACKGROUND Serum lactate dehydrogenase (LDH) is elevated in various diseases. OBJECTIVES To analyze serum LDH as a distinguishing clinical biomarker and as a predictor of in-hospital outcome in admitted medical patients. METHODS We analyzed a cohort of all 158 patients with very high isolated LDH (LDH > or = 800 IU/ml without concomitant elevations of alanine aminotransferase and aspartate ...

Induction of lactic dehydrogenase (LDH) antibody with porcine LDH in L1210 leukemia-bearing DBA/2 mice can induce remissions of the disease. The concurrent, limited use of a cytotoxic agent (azathioprine) in combination with LDH has been investigated and found to be advantageous in terms of obtaining a greater number of prolonged remis sions (over 150 days) than does the use of LDH alone. The p...

By YALE RABINOWITL AND ALBERT A. D rz With the technical assistance of Tina Lubrano, Inge Schimo and Betty A. Wilhite II ESULTS OF A STUDY OF CHANGES in lactic dehydrogenase (LDH) occurring in cultures of normal human lymphocytes were reported recently.’ It was shown that lymphocytes in cultures without phytohemagglutinin (PHA) showed little change in total LDH activity or in isozyme patterns; ...

BACKGROUND The aims of this study were to analyze the prognostic value of baseline lactate dehydrogenase (LDH) among nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT), and to evaluate the potential application of LDH in monitoring treatment efficacy dynamically. MATERIAL AND METHODS From June 2005 to December 2010, 1188 patients with non-metastati...

609 Abstract: In order to determine the seminal activity of LDH-C4 and to investigate its correlation with other fertility indexes, we studed total LDH, total CK avtivities, and LDH-C4 in relation to sperm count, motility and sperm motility index (SMI). SMI is the measurement of electro-optical fluctuations caused by motile sperm. Total LDH and total CK were determined with a Technicon RA 1000 ...

Ebselen is a seleno compound whose antioxidant properties have been attributed to its thiol-peroxidase and thioredoxin-like activity. However, the excessive oxidation of thiols can be potentially toxic. Thus, this work investigated whether lactate dehydrogenase (LDH) can be a possible in vitro target to the toxicity of ebselen, in comparison with diphenyl diselenide [(PhSe)(2)] and diphenyl dit...

A cDNA that encodes the heart-type lactate dehydrogenase (LDH-B) from the teleost fish Fundulus heteroclitus was cloned and sequenced. The protein encoded by the cDNA was analyzed in relation to 13 LDH proteins from a variety of taxa. One of the deductions from this analysis is that LDH-B proteins have residues in the active site that are unique and that may be important in determining the bioc...

Layered double hydroxides (LDHs), also known as hydrotalcite-like anionic clays, have been investigated widely as promising electrochemical active materials. Due to the inherently weak conductivity, the electrochemical properties of LDHs were improved typically by utilization of either functional molecules intercalated between LDH interlayer galleries, or proteins confined between exfoliated LD...

LDH isoenzyme (s) linked to IgG of the lambda type found in the serum of a patient having had myocardial infarction is reported. This LDH-IgG complex has almost no enzymatic activity. It was found that the IgG of the patient acted as an inhibitor of LDH. LDH activity in normal human serum was inhibited and abnormal patterns of LDH isoenzyme (s) appeared when certain amounts of the patient's ser...