background: light chain (lc) and heavy chain carboxyterminal subdomain (hcc) fragments are the most important parts of tetanus neurotoxin (tent) which play key roles in toxicity and binding of tent, respectively. in the present study, these two fragments were cloned and expressed in a prokaryotic system and their identity was confirmed using anti-tent specific polyclonal and monoclonal antibodi...

conclusions this information provides an explanation for the previously valuable literature on the functions of lncrnas and suggest for the novel therapeutic targeting. results the lncrnas hottip, h19, hotair, malat1, antisense igf2r (air), hoxa13, gtl2 (also called meg3) and uc002mb have been reported in association with hcc. besides, this study predicted that eif4aiii, ptb and fus were the mo...

conclusions the established method has an acceptable performance in quantifying yb-1. in addition, serum yb-1 may aid in the diagnosis of hcc. results the developed method was linear to 150 μg/l of yb-1 with a minimum detection limit of 0.01 μg/l. the average recoveries were between 93.9% and 109.0%. the mean intra- and inter-assay coefficients of variation (cvs) were 4.0-4.8% and 8.2-10.2%, re...

The incidence of non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) is increasing annually as the metabolic syndrome factors increase. This study aimed to analyze involvement periodontopathic bacteria in NASH-related HCC (NASH-HCC). Questionnaire investigation, periodontal examination, medical and specimen collection (saliva, mouth-rinsed water, peripheral blood) were p...

results the tlr3 protein in the ach group tended toward reduction although the p value of the comparison between the ach group and hd group was not statistically significant. the tlr3 levels in the hcc, ac, and cir groups were higher than those in the hd and ach groups. tlr3 was not interrelated with all costimulation proteins in the dcs and t cells in all five groups. no group presented any in...

(HCC) is the second most common cause of cancer-related death worldwide [1], generally arising on the background of chronic liver diseases such as chronic viral hepatitis, alcohol-induced liver injury, or fatty liver disease. So far, classification proposals for HCC based on molecular markers are not yet routinely applied in surgical pathology or clinical management of HCC patients. This stands...

Abstract Background Hepatocellular carcinoma (HCC) can grow in a mosaic pattern, often combined with various non-hepatocellular cells. However, HCC neuroendocrine (NEC) component is rarely reported, and its clinical features, origin, diagnosis, behavior have not been established. In the literature, mixed HCC–NEC tumors are categorized as either collision type or type, depending on their microsc...

With an expected incidence of more than 1 million cases by 2025, liver cancer remains a problem for world health. over 90% cases, hepatocellular carcinoma (HCC) is the most prevalent kind cancer. In this review, we presented range experimental therapeutics patients with advanced HCC, successes and failures new treatments, areas future development, evaluation dose-limiting toxicity in different ...