We investigate the autoreducibility and mitoticity of complete sets for several classes with respect to different polynomial-time and logarithmic-space reducibility notions. Previous work in this area focused on polynomial-time reducibility notions. Here we obtain new mitoticity and autoreducibility results for the classes EXP and NEXP with respect to some restricted truth-table reductions (e.g...

Heart transplantation (HTx) is the treatment of choice for end-stage heart failure but the limited availability of heart's donors still represents a major issue. So long-term mechanical circulatory support (MCS) has been proposed as an alternative treatment option to assist patients scheduled on HTx waiting list bridging them for a variable time period to cardiac transplantation-the so-called b...

OBJECTIVE To evaluate bone mineral status and metabolism in a cohort of patients with Williams-Beuren syndrome (WBS). PATIENTS Thirty-one children (15 females, 16 males; mean age 9.6±2.74 years) and 10 young adults (6 females, 4 males; mean age 21.4±5.11 years) with WBS were cross-sectionally evaluated and compared with two age-, sex-, and body-size-matched paediatric (155 subjects, 75 female...

Correspondence: Professeur A Perdriger Service de rhumatologie, CHU de rennes, Hôpital sud, 16 boulevard de Bulgarie, 35056 rennes Cedex, France Tel +33 (02) 99 26 71 40 Fax +33 (02) 99 26 71 90 Email [email protected] Abstract: Infliximab was the first monoclonal antibody to human necrosis factor alpha (TNFα) developed for treating rheumatoid arthritis (RA). This chimeric antibody ...

The synthesis of covalent organic frameworks (COFs) based on a novel thiophene-extended benzotrithiophene (BTT) building block is described, which in combination with triazine-based amines (1,3,5-triazine-2,4,6-triyl)trianiline (TTA) or (1,3,5-triazine-2,4,6-triyl)tris(([1,1´-biphenyl]-4-amine)) (TTTBA)) affords crystalline, and porous imine-linked COFs, BTT TTA TTTBA, surface areas as high 932...

Objective. Klinefelter syndrome (KS) has long-term consequences on bone health. However, studies regarding bone status and metabolism during childhood and adolescence are very rare. Patients. This cross-sectional study involved 40 (mean age: 13.7 ± 3.8 years) KS children and adolescents and 80 age-matched healthy subjects. For both patient and control groups, we evaluated serum levels of ionise...

AIMS To evaluate the clinical and cost-effectiveness of left ventricular (LV) assist devices (LVADs) as a bridge to transplant (BTT) for people with end-stage heart failure (ESHF) through a systematic review and economic evaluation. METHODS AND RESULTS The systematic review and economic evaluation was conducted according to internationally recognized methods. The search strategy identified sy...

PurposeLeft Ventricular Assist Device (LVAD) as a bridge to heart transplantation (BTT) has been described risk factor for post-heart (HT) sensitization and rejection. Donor-derived cell-free-DNA (dd-cfDNA) test is noninvasive method surveillance of allograft injury. We sought characterize dd-cfDNA in LVAD-BTT recipients compared non-LVAD patients its impact on post-HT outcomes.MethodsPatients ...

Correspondence: Andrea Pession Oncologia ed ematologia Pediatrica “Lalla Seràgnoli”, Clinica Pediatrica, Università di Bologna, via Massarenti, 11, 40138, Bologna, italy email [email protected] Abstract: Acute lymphoblastic leukemia (ALL) accounts for almost 4000 cases annually in the United States, approximately two thirds of which are in children and adolescents. Treatment results of AL...