Prasugrel, a third-generation thienopyridine antiplatelet agent, demonstrated superior efficacy to clopidogrel but with an increased risk of bleeding in the phase III pivotal registration Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel-Thrombolysis in Myocardial Infarction (TRITON-TIMI 38). This article reviews and discusses select components...

wo reports (1,2) in this issue of the Journal describe the esults of the PROTECT–TIMI-30 (Randomized Trial to valuate the Relative Protection Against Post-Percutaneous oronary Intervention Microvascular Dysfunction, Ischemia, nd Inflammation Among Antiplatelet and Antithrombotic gents–Thrombolysis In Myocardial Infarction-30) study, a andomized trial whose primary outcome was unexpected. esults...

This paper describes the in-hospital outcome of urgent percutaneous coronary interventions (PCI) with delayed PCI in patients suffering from non-ST-segment elevation acute coronary syndromes (NSTE-ACS). The time when the PCI should be performed is still under debate. Results from 620 patients hospitalized in Silesian Centre of Heart Diseases in Zabrze in years 20022005 were included in this stu...

BACKGROUND Primary percutaneous coronary intervention (PCI) is the main treatment for patients with ST-segment elevation myocardial infarction (STEMI). We investigated factors affecting the major complications of this procedure. METHODS This case-control study assessed 200 patients receiving primary PCI for STEMI. Effects of some factors including age, sex, coronary artery risk factors, left ...

Although the TIMI (Thrombolysis In Myocardial Infarction) flow grade classification scheme is widely used to assess angiographic outcomes, it is limited by poor reproducibility and its categoric nature. The corrected TIMI frame count (CTFC) is a simple, more objective continuous variable index of coronary blood flow that can be broadly and inexpensively applied. This measure of the time for dye...

OBJECTIVE We aimed to investigate the correlation between the success of recanalization and a modified version of the Qureshi grading system in acute ischemic stroke patients. METHODS We retrospectively analyzed the intra-arterial thrombolysis (IAT) records of 37 patients who were evaluated by Thrombolysis in Myocardial Infarction (TIMI) and a modified version of the Qureshi grading systems a...

Background: Primary angioplasty improves outcomes of acute myocardial infarction (AMI). However, in the highest risk subgroups, the mortality remains high despite modern catheterbased reperfusion therapy. This study analyzed patients with AMI caused by the left main coronary artery unstable lesion, a subgroup considered to be associated with very high early mortality. Methods: A multicenter reg...