Randomization as a method of experimental control has been extensively used in clinical trials. Generating the randomization schedule has been an essential part of some trials. We discuss how to use SAS programming and SAS PROC PLAN to generate the randomization schedule. The issues related to randomization are also discussed. Case studies are used to illustrate the use of SAS programming and S...

Kent and O'Quigley (1988) apply the concept of information gain to define a measure of dependence (R-squared measure) between explanatory variables and a censored response variable within the framework of the Cox model. Two SAS macros to calculate this measure are presented. The first one is based on a Newton-Raphson search and makes use of the SAS IML procedure. The second one is a simple grid...

 Abstract— This paper studies the semi-analytic solution (SAS) of a power system’s differential-algebraic equation. A SAS is a closed-form function of symbolic variables including time, the initial state and the parameters on system operating conditions, and hence able to directly give trajectories on system state variables, which are accurate for at least a certain time window. A two-stage SA...

Preparation of the motor system for movement execution involves an increase in excitability of motor pathways. In a reaction time task paradigm, a startling auditory stimulus (SAS) delivered together with the imperative signal (IS) shortens reaction time significantly. In self-generated tasks we considered that an appropriately timed SAS would have similar effects. Eight subjects performed a ba...

This paper provides a web-based system using SAS, HTML and CGI/PERL to provide rudimentary and complex Sybase DBMS performance metrics for Unix based system operations. Sybase SQL Server performance data is collected by Sybase Historical Server allowing for the collection of performance information with minimal impact on the server. The SAS System (Base SAS, Macro, STAT and SAS/Graph) is especi...

BACKGROUND Idiosyncratic drug reactions such as hepatotoxicity and blood dyscrasias represent one of the major causes of drug withdrawal from the market. According to the reactive metabolite (RM) concept, this may be due to the metabolic activation of structural alerts (SAs), functionalities in the drug molecule that are susceptible to bioactivation resulting in RMs. The relationship, however, ...

Testing for the presence of linkage disequilibrium (LD) and measuring its value is important in statistical genetics. LD deals with the correlation of genetic variation at two or more loci in the genome within a given population. PROC ALLELE in SAS/GENETICS provides a variety of pair-wise LD measures that are related to the well-known Pearson correlation r. Different statistical tests of linkag...

Centrioles are cylindrical cell organelles with a ninefold symmetric peripheral microtubule array that is essential to template cilia and flagella. They are built around a central cartwheel assembly that is organized through homo-oligomerization of the centriolar protein SAS-6, but whether SAS-6 self-assembly can dictate cartwheel and thereby centriole symmetry is unclear. Here we show that Lei...

For high-throughput monitoring of the residues of sulfonamides (SAs) in edible animal tissues, a novel hapten and monoclonal-based indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) was developed. The novel hapten was synthesized and conjugated to carrier protein as immunogen. The spleen cells of the inoculated mice expressing group-specificity against SAs were fused. The obtaine...