The orbital and medial prefrontal cortex (OMPFC) receives inputs from the CA1/subicular (CA1/S) region of the ventral hippocampus and the basolateral nucleus of the amygdala (BLA). Despite many studies about these projections, little is known as to how CA1/S and BLA inputs converge and interact within the OMPFC. Extracellular recordings of single-unit activity in the OMPFC were performed in sod...

The CA1-projecting axons of CA3 pyramidal cells, called Schaffer collaterals, constitute one of the major information flow routes in the hippocampal formation. Recent anatomical studies have revealed the non-random structural connectivity between CA3 and CA1, but little is known regarding the functional connectivity (i.e. how CA3 network activity is functionally transmitted downstream to the CA...

the effect of cysteamine, a somatostatin depletor, on synaptic plasticity induced by tetanic and paired-pulse stimulation was investigated in rat hippocampal ca1. for this purpose, hippocampal slices from saline (1 ml/kg, s.c.) and cysteamine (200 fig/kg, s.c.)-treated and intact rats were used. population spikes were recorded following schaffer collateral stimulation. to induce ltp, primed bur...

Signal propagation from mossy fibers to CA1 neurons was investigated in rat hippocampal slices by a combination of electrical and optical recordings. The slices were prepared by oblique sectioning of the middle part of the hippocampus to preserve fiber connections. The mossy fibers were stimulated to induce population spikes (PSs) and excitatory postsynaptic potentials in the middle part of the...

The effectiveness of tetraethylammonium (TEA) and high-frequency stimulation (HFS) in inducing long-term synaptic modification is compared in CA1 and dentate gyrus (DG) in vitro. High-frequency stimulation induces long-term potentiation (LTP) at synapses of both perforant path-DG granule cell and Schaffer collateralCA1 pyramidal cell pathways. By contrast, TEA (25 mM) induces long-term depressi...

CA3 and subiculum are hippocampal formation regions that can initiate seizure activity because each has a substantial intrinsic excitatory connectivity. We studied the intrinsic connectivity of area CA1 by exploring the spread of synchronous population discharges in ventral hippocampal slices from rats using a recording chamber that permitted multiple simultaneous extracellular recordings along...

We examined the topographic organization of the connections of the CA3 field of the macaque monkey hippocampus. Discrete anterograde and retrograde tracer injections were made at various positions within CA3 and CA1. The projections from CA3 to CA1 (Schaffer collaterals), which terminate in the strata radiatum, pyramidale, and oriens, are present throughout the entire transverse extent of CA1. ...

BACKGROUND AND AIM The anatomical connections of septum and hippocampus and the influence of cholinergic and glutamatergic projections in these sites have been reported. In the present study, the effect of pre-training intra-dorsal hippocampal (CA1) and intra-medial septal (MS) administration of scopolamine, a nonselective muscarinic acetylcholine antagonist, and NMDA receptor agents and their ...

Previous studies have focused considerable attention on the effects of estrogen on excitatory synaptic input to hippocampal CA1 pyramidal cells. Estrogen increases the density of dendritic spines and synapses on CA1 pyramidal cells and increases the sensitivity of these cells to excitatory synaptic input. Little is known, however, about the effects of estrogen on inhibitory synaptic input to CA...

سابقه و هدف: به ­دلیل توسعه رشد جمعیت انسان، نیاز انسان منابع ضروری افزایش یافته است. فعالیت‌های مربوط صنایع همچنین کشاورزی به­ طور گسترده‌ای زمین‌های را آلوده کرده ترکیبات نفتی فلزات سنگین هر دو از آلاینده‌های رایج موجود در خاک‌هایی هستند که با فاضلاب تصفیه نشده آبیاری شده‌اند سلامت محیط زیست خطر مواجه می‌کنند. آلودگی خاک می‌تواند سبب کاهش امکان زراعت، نهایت تولید غذا برای شود. جنوب شهر تهران ...