Booth, Barbara A., Mary Boes, Brian L. Dake, and Robert S. Bar. Isolation and characterization of plasmingenerated bioactive fragments of IGFBP-3. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E450–E454, 1999.—Insulin-like growth factor-binding protein-3 (IGFBP-3) was digested with plasmin, and the proteolytic fragments were isolated by HPLC and tested for bioactivity as measured by stimulation ...

AKI YAMADA,1 SUSUMU OHYA,2 MASARU HIRANO,2 MINORU WATANABE,2 MICHAEL P. WALSH,3 AND YUJI IMAIZUMI1 1Department of Pharmacology and Therapeutics and 2Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan; and 3Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Ca...

Eaton, Philip, Jian-Mei Li, David J. Hearse, and Michael J. Shattock. Formation of 4-hydroxy-2-nonenalmodified proteins in ischemic rat heart. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H935–H943, 1999.—4-Hydroxy-2nonenal (HNE) is a major lipid peroxidation product formed during oxidative stress. Because of its reactivity with nucleophilic compounds, particularly metabolites and proteins co...

Putman, C. T., M. P. Matsos, E. Hultman, N. L. Jones, and G. J. F. Heigenhauser. Pyruvate dehydrogenase activation in inactive muscle during and after maximal exercise in men. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E483– E488, 1999.—Pyruvate dehydrogenase activity (PDHa) and acetyl-group accumulation were examined in the inactive deltoid muscle in response to maximal leg exercise in men. ...

Wyman, Bradley T., William C. Hunter, Frits W. Prinzen, and Elliot R. McVeigh. Mapping propagation of mechanical activation in the paced heart with MRI tagging. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H881–H891, 1999.— The temporal evolution of three-dimensional (3-D) strain maps derived from magnetic resonance imaging (MRI) tagging were used to noninvasively evaluate mechanical activati...

The reliability of the narrative of the Biblical Exodus has been subject of heated debate for decades. Recent archaeological studies seem to provide new insight of the exodus path, and although with a still controversial chronology, the effects of the Minoan Santorini eruption have been proposed as a likely explanation of the biblical plagues. Particularly, it has been suggested that flooding b...

Olszewski, Michal A., N. Edward Robinson, Feng-Xia Zhu, Xiang-Yang Zhang and Patricia K. Tithof. Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. Am. J. Physiol. 276 (Lung Cell. Mol. Physiol. 20): L522–L529, 1999.— Neutrophilic inflammation in small airways (SA) and bronchospasm mediated via muscarinic receptors are features of chroni...

Boulton, M., M. Flessner, D. Armstrong, R. Mohamed, J. Hay, and M. Johnston. Contribution of extracranial lymphatics and arachnoid villi to the clearance of a CSF tracer in the rat. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R818–R823, 1999.—The objective of this study was to determine the relative roles of arachnoid villi and cervical lymphatics in the clearance of a cereb...

Farge, Emmanuel, David M. Ojcius, Agathe Subtil, and Alice Dautry-Varsat. Enhancement of endocytosis due to aminophospholipid transport across the plasma membrane of living cells. Am. J. Physiol. 276 (Cell Physiol. 45): C725– C733, 1999.—Formation of intracellular vesicles is initiated by membrane budding. Here we test the hypothesis that the plasma membrane surface area asymmetry could be a dr...

Maréchal, Hervé, Hélene Jammes, Bernard Rossignol, and Philippe Mauduit. EGF precursor mRNA and membrane-associated EGF precursor protein in rat exorbital lacrimal gland. Am. J. Physiol. 276 (Cell Physiol. 45): C734– C746, 1999.—This study was designed to demonstrate the presence of epidermal growth factor (EGF) in the rat exorbital lacrimal gland. EGF precursor gene transcription was demonstra...