نتایج جستجو برای: موش nod

تعداد نتایج: 18830  

2012
Azadeh Hosseini-Tabatabaei Reza Baradar Jalili Yunyuan Li Ruhangiz T. Kilani Alireza Moeen Rezakhanlou Aziz Ghahary

Indoleamine 2,3-dioxygenase (IDO) can locally suppress T cell-mediated immune responses. It has been shown that defective self-tolerance in early prediabetic female non-obese diabetic (NOD) mice can be attributed to the impaired interferon-gamma (IFN-γ)- induced IDO expression in dendritic cells of these animals. As IFN-γ can induce IDO in both dendritic cells and fibroblasts, we asked the ques...

Journal: :Arthritis Research & Therapy 2008
Manon E Wildenberg Cornelia G van Helden-Meeuwsen Hemmo A Drexhage Marjan A Versnel

INTRODUCTION In the nonobese diabetic (NOD) mouse model of Sjögren's syndrome, lymphocytic infiltration is preceded by an accumulation of dendritic cells in the submandibular glands (SMGs). NOD mice also exhibit an increased frequency of mature, fractalkine receptor (CX3C chemokine receptor [CX3CR]1) expressing monocytes, which are considered to be precursors for tissue dendritic cells. To unra...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2007
Kyoung Moo Choi Jin Zhu Gary J Stoltz Steven Vernino Michael Camilleri Joseph H Szurszewski Simon J Gibbons Gianrico Farrugia

Animal studies on diabetic gastroparesis are limited by inability to follow gastric emptying changes in the same mouse. The study aim was to validate a nonlethal gastric emptying method in nonobese diabetic (NOD) LtJ mice, a model of type 1 diabetes, and study sequential changes with age and early diabetic status. The reliability and responsiveness of a [(13)C]octanoic acid breath test in NOD L...

Journal: :Journal of immunology 2000
P Chaturvedi B Agrawal M Zechel E Lee-Chan B Singh

We explored T cell responses to the self class II MHC (I-Ag7) beta-chain-derived peptides in diabetic and prediabetic nonobese diabetic (NOD) mice. We found that one of these immunodominant epitopes of the beta-chain of I-Ag7 molecule, peptide 54-76, could regulate autoimmunity leading to diabetes in NOD mice. T cells from prediabetic young NOD mice do not respond to the peptide 54-76, but T ce...

Journal: :Current opinion in plant biology 1999
J A Downie S A Walker

The focus of research on signalling in Rhizobium-legume interactions has moved from understanding the structure and synthesis of rhizobially made Nod factors, towards an analysis of how they function in plants. Nod-factor-induced changes in ion fluxes across membranes, followed by establishment of an oscillation of intracellular Ca(2+) concentration, point to the involvement of a receptor-media...

Journal: :The Plant journal : for cell and molecular biology 2006
Hiroki Miwa Jongho Sun Giles E D Oldroyd J Allan Downie

Rhizobium-made Nod factors induce rapid changes in both Ca(2+) and gene expression. Mutations and inhibitors that abolish Nod-factor-induced Ca(2+) spiking block gene induction, indicating a specific role for Ca(2+) spiking in signal transduction. We used transgenic Medicago truncatula expressing a "cameleon" Ca(2+) sensor to assess the relationship between Nod-factor-induced Ca(2+) spiking and...

Journal: :Diabetes 1999
T G Markees D V Serreze N E Phillips C H Sorli E J Gordon L D Shultz R J Noelle B A Woda D L Greiner J P Mordes A A Rossini

A protocol consisting of a single donor-specific transfusion (DST) plus a brief course of anti-CD154 monoclonal antibody (anti-CD40 ligand mAb) induces permanent islet allograft survival in chemically diabetic mice, but its efficacy in mice with autoimmune diabetes is unknown. Confirming a previous report, we first observed that treatment of young female NOD mice with anti-CD154 mAb reduced the...

Journal: :The Journal of Experimental Medicine 1997
Joan Verdaguer Dennis Schmidt Abdelaziz Amrani Brad Anderson Nuzhat Averill Pere Santamaria

It has been established that insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice results from a CD4+ and CD8+ T cell-dependent autoimmune process directed against the pancreatic beta cells. The precise roles that beta cell-reactive CD8+ and CD4+ T cells play in the disease process, however, remain ill defined. Here we have investigated whether naive beta cell-specific CD8...

2018
Xue-Dao He Yan-Mei Guo Raj K. Goyal

Background Hyperglycemia has been reported to enhance vagovagal reflex that causes the release of inhibitory neurotransmitter, nitric oxide (NO), at the neuromuscular junction in the antrum to relax the antrum and slow gastric emptying by stimulating glucose-sensitive afferent neurons. However, hyperglycemia has also been reported to cause fast gastric emptying that may be due to suppression of...

Journal: :Journal of bacteriology 1985
R V Masterson R K Prakash A G Atherly

Southern hybridization with nif (nitrogen fixation) and nod (nodulation) DNA probes from Rhizobium meliloti against intact plasmid DNA of Rhizobium japonicum and Bradyrhizobium japonicum strains indicated that both nif and nod sequences are on plasmid DNA in most R. japonicum strains. An exception is found with R. japonicum strain USDA194 and all B. japonicum strains where nif and nod sequences...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید