Despite substantial premarket efforts, a significant portion of approved drugs has been withdrawn from the market for safety reasons. The deleterious impact of nonsynonymous substitutions predicted by the SIFT algorithm on structure and function of drug-related proteins was evaluated for 2504 personal genomes. Both withdrawn (n = 154) and precautionary (Beers criteria (n = 90), and US FDA pharm...

Publication of “Updating the Beers Criteria for Potentially Inappropriate Medication Use in Older Adults” again raises many of the same issues about the list’s development and uses—intended and unintentional—since its original publication in 1991 and subsequent 1997 revision. The list was adopted nearly verbatim in the CMS surveyor guidance for Federal Tags F329 and 429, in effect, codifying it...

Non-Saccharomyces yeasts represent a great source of biodiversity for the production new beer styles, since they can be used in different industrial areas, as pure culture starters, co-fermentation with Saccharomyces, and spontaneous fermentation (lambic gueuze production, main contribution Brettanomyces yeast). The process lambic is characterized by phases characteristic predominance microorga...

Nowadays, non-alcoholic (NAB) and low-alcoholic beers (LAB) still significantly suffer from staling defects when fresh, partially due to absence of ethanol as antioxidant. In the current work, fate flavan-3-ols (monomers, dimers, trimers) bitter compounds (isohumulones, humulinones, etc.) 11 commercial NABLABs available on Belgian market was monitored through one year aging at 20 °C in dark. Fr...

CRIME study. Age Ageing 2014; 43: 766–72. 6. American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2012; 60: 616–31. 7. Gallagher P, Ryan C, Byrne S, Kennedy J, O’Mahony D. STOPP (Screening Tool of Older Person’s Prescriptions) and START (Screening Too...