نتایج جستجو برای: مسیر ras

تعداد نتایج: 54191  

Journal: :Anticancer research 2010
Moshe Rogosnitzky Rachel Danks

BACKGROUND K-ras mutation in a tumour is a powerful negative predictor for treatment success. Identifying tumour K-ras mutation is complex, and could be simplified by an appropriate blood test. Clinical studies were identified in which K-ras mutation status was assessed in both blood and tumour to ascertain whether blood K-ras mutation is predictive of tumour K-ras mutation. Between 29% and 100...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Xiaoqin Wu Jieqiong Jiang Yi Wan John P Giesy Jianying Hu

Deformed amphibians have been observed in eutrophic habitats, and some clues point to the retinoic acids (RAs) or RA mimics. However, RAs are generally thought of as vertebrate-specific hormones, and there was no evidence that RAs exist in cyanobacteria or algae blooms. By analyzing RAs and their analogs 4-oxo-RAs in natural cyanobacteria blooms and cultures of cyanobacteria and algae, we showe...

2006
Todd A. Thompson Kwanghee Kim Michael N. Gould

Exclusive activation of either the Harvey-, Kirsten-, or N-ros gene is often found in human and rodent cancers, although the mechanisms responsible for tissue-specific ras gene activation are poorly understood. In this study, the contribution of ras gene expression and Ras protein activity to the tissue-specificity of ras gene activation was investigated using the rat mammary carcinogenesis mod...

2015
Simone Bido Nicola Solari Marzia Indrigo Angela D’Antoni Riccardo Brambilla Michele Morari Stefania Fasano

OBJECTIVE Recent findings have shown that pharmacogenetic manipulations of the Ras-ERK pathway provide a therapeutic means to tackle l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia (LID). First, we investigated whether a prolonged l-DOPA treatment differentially affected ERK signaling in medium spiny neurons of the direct pathway (dMSNs) and in cholinergic aspiny interneurons (ChIs) an...

Journal: :journal of dentistry, tehran university of medical sciences 0
a. darbandi a. ganbari

statement of problem: recurrent aphthous stomatitis (ras) is one of the most common diseases affecting human oral mucosa. the etiology of this disease remains unclear; therefore a definitive treatment has not yet been established and corticosteroids might be prescribed to reduce the symptoms associated with ras. purpose: the aim of this study was to determine the effects of a mouthwash containi...

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2011

2017
J Vidal L Muinelo A Dalmases F Jones D Edelstein M Iglesias M Orrillo A Abalo C Rodríguez E Brozos Y Vidal S Candamio F Vázquez J Ruiz M Guix L Visa V Sikri J Albanell B Bellosillo R López C Montagut

Background RAS assessment is mandatory for therapy decision in metastatic colorectal cancer (mCRC) patients. This determination is based on tumor tissue, however, genotyping of circulating tumor (ct)DNA offers clear advantages as a minimally invasive method that represents tumor heterogeneity. Our study aims to evaluate the use of ctDNA as an alternative for determining baseline RAS status and ...

Journal: :International journal of experimental pathology 2014
Feijun Luo George Poulogiannis Hongtao Ye Rifat Hamoudi Gehong Dong Wenyan Zhang Ashraf E K Ibrahim Mark J Arends

K-ras mutations are found in ~40% of human colorectal adenomas and carcinomas and contribute to colorectal tumour formation at an early stage. Wild-type K-ras has been reported to be deleted in some tumours, but the consequences of changes in wild-type K-ras copy number for experimental colorectal carcinogenesis have not been investigated. To characterize the effects of K-ras copy number change...

Journal: :Cancer research 1991
T Mukhopadhyay M Tainsky A C Cavender J A Roth

A human lung cancer cell line (H460a) with a homozygous spontaneous K-ras mutation was transfected with a recombinant plasmid that synthesizes a 2-kilobase genomic segment of the K-ras protooncogene in antisense orientation. Translation of the mutated K-ras mRNA in H460a cells was specifically inhibited, whereas expression of H-ras and N-ras was unchanged. A 3-fold growth inhibition occurred in...

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