In subacute cutaneous lupus eryhematosus (SCLE) the cutaneous antigens constitute the main source of Ro and La autoantigens. The aim of this investigation was to demonstrate if UV light increases the availability of Ro autoantigen in the skin, also the blocking effect of Ac-DEVD-CMK a caspase inhibitor was assessed. For this purpose newborn Balb/c mice were UVB irradiated (5-30 mJ/cm(2)) equiva...

A mesoporous Li 4 Ti 5 O 12 /C nanocomposite is synthesized by a nanocasting technique using the porous carbon material CMK-3 as a hard template. Modifi ed CMK-3 template is impregnated with Li 4 Ti 5 O 12 precursor, followed by heat treatment at 750 ° C for 6 h under N 2 . Li 4 Ti 5 O 12 nanocrystals of up to several tens of nanometers are successfully synthesized in micrometer-sized porous ca...

Abstract Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to also COVID-19 severity. Here, we show a distinct mechanism by which N protein promotes NLRP3 inflammasome activation induce hyperinflammation. facilitates maturation proinflammatory cytokines and induces cultured cells mice. Mechanis...

Many different biochemical signaling pathways regulate integrin activation through the integrin cytoplasmic tail. Here, we describe a new role for α-actinin in inside-out integrin activation. In resting human platelets, α-actinin was associated with αIIbβ3, whereas inside-out signaling (αIIbβ3 activation signals) from protease-activated receptors (PARs) dephosphorylated and dissociated α-actini...

Goblet cell hyperplasia in the superficial airway epithelia is a signature pathological feature of chronic bronchitis and cystic fibrosis. In these chronic inflammatory airway diseases, neutrophil elastase (NE) is found in high concentrations in the epithelial lining fluid. NE has been reported to trigger mucin secretion and increase mucin gene expression in vitro. We hypothesized that chronic ...

BACKGROUND Children with Down syndrome (DS) have increased risk for developing AML (DS-AMKL), and they usually experience severe therapy-related toxicities compared to non DS-AMKL. Refractory/relapsed disease has very poor outcome, and patients would benefit from novel, less toxic, therapeutic strategies that overcome resistance. Relapse/resistance are linked to cancer stem cells with high alde...