This valediction to the late Sir Harold Ridley commemorates the 50th year of his first publication in the St Thomas’s Hospital Report, describing his pioneer undertaking to research, design, and implant an intraocular lens to correct aphakia. Dissatisfied with the poor acuity and loss of binocular single vision following unilateral cataract extraction and the poor outcome, particularly in child...

IT is written in the Bible that wve should take time "to praise famous men and our fathers that begat us." This year-the centenary year of the Ulster Medical Society-seemed an appropriate point of time for such remembrance and reflection. I chose, therefore, the name of one, William Whitla, a past President and benefactor of our Society, as the subject of my address. On 11th December, 1933, Sir...

How alternative chromatin-based regulatory states can be made stable and heritable in order to provide robust epigenetic memory is poorly understood. Here, we develop a stochastic model of the silencing system in Saccharomyces cerevisiae that incorporates cooperative binding of the repressive SIR complex and antisilencing histone modifications, in addition to positive feedback in Sir2 recruitme...

Patients on maintenance dialysis have increased risk for cancer, especially in the kidney and urinary tract. In a retrospective cohort of 831,804 patients starting dialysis during 1980 to 1994 in the United States, Europe, or Australia and New Zealand, standardized incidence ratios (SIR) with 95% confidence intervals (CI) were calculated for kidney and bladder cancers. Risks for cancers of the ...

Proton cyclotron waves (PCWs) upstream from Mars are generated by ion–ion instabilities due to the interaction between solar wind and pickup protons that originate extended hydrogen (H) exosphere of Mars, indicating a loss H interplanetary space. Their occurrences properties associated with nominal conditions have been widely studied, but relatively little is known about PCW activity under extr...

outline of the events which make this volume so well worthy of perusal. Brodie's character as a man deserves very careful study; and the insight which the book gives us into the condition of the profession and the state of society at the time when he lived is by no means its least instructive part. Brodie had many interests outside his profession, and his views on various questions of psycholog...

ACKNOWLEDGEMENTS The medical case histories referred to are the original MS records now bound in one volume and filed in the hospital on the island. For background information the literature is very meagre, but I have had recourse to the following: St. Helena by Philip Gosse, (London, Cassell, 1938); Six Months on Ascension by Mrs. Gill (London, John Mufray); Darwin and The Beagle, by Alan Moor...

In 1945 I was looking for a job, after having spent a short post-war convalescence as a junior assistant in the Medical Unit at St. Thomas's Hospital, when I had the good fortune to be introduced to Dr Avery Jones. He had just then had the idea that clues to the causes of gastric and duodenal ulcers might be obtained if differences could be found in the frequency with which they occurred in men...