PURPOSE Seizures in the developing brain cause less macroscopic structural damage than do seizures in adulthood, but accumulating evidence shows that seizures early in life can be associated with persistent behavioral and cognitive impairments. We previously showed that long-term spatial memory in the eight-arm radial-arm maze was impaired in rats that experienced a single episode of kainic aci...

Objective: In this study, we aimed to analyze the effects and underlying mechanisms of LPM570065 on behavioral phenotypes in rats with generalized anxiety disorder (GAD).Methods: The chronic unpredictable mild stress (CUMS) were used observe results LPM570065. Total 72 male Sprague Dawley divided into control, vehicle (0.5% CMC-Na), (32 mg/kg) diazepam (3 groups, 12 each group. Anxiety-like beh...

introduction: effective perception of fear signals is crucial for organism survival. when threated, the organism indicates defensive behaviors. methods: elevated plus–maze has high efficiency for measurement of fear behavior and is widly used for fear behavior determination. increase in two parameters percent of openarm entries (%oae) and percent of time spent in the open-arm (%oat) in the elev...

Systematic observations of the defensive behavior of wild rodents have greatly informed the experimental study of anxiety and its neural substrates in laboratory animals. However, as the former work has been almost exclusively carried out in rats, few data are available concerning the reactivity of wild mice to standardized tests of anxiety-related behavior. In the present experiments, we emplo...

The goal of this study was to examine the effects of early life experiences on the subsequent expression of traits characteristic of social monogamy in prairie voles (Microtus ochrogaster). During cage changes parents and their offspring were either transferred between cages in a cup (zero manipulation, MAN0) or with a gloved hand (one manipulation, MAN1). Following weaning the offspring were t...

The present study was aimed to screen neuroprotective effects of lantana camara in BPA induced-cognitive dysfunction and oxidative stress rats. In methodology animals were divided into 5 groups. Group I serve as vehicle control group administered with 2 ml normal saline. II 50 µg/kg for 21 days. III IV served drug treated pre 1 week methanolic extract L.camara (250 500 mg/kg bw/day orally). V s...

Abstract Background Alysicarpus glumaceus has been reported to be used in managing patients with neuropsychiatric disorders. This work aimed determine the behavioural effects of aerial parts murine models. Method The drug extract was evaluated using elevated zero maze (EZM), stair case test (SCT) and open field (OFT) while beam walking for motor coordination deficit stimulant activity mice at d...

Introduction: Previous studies have shown that cannabinoidergic system is involved in anxiety. However, there are controversial reports in the experimental studies. The aim of this study is to evaluate the effect of pharmacological stimulation or blocking of CB1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze (EPM) test in rat. The EPM is o...