It's impossible to discuss a piece of Vic's work without relating it to the other pieces. Everything fits together within an overall strategy of applying the empirical scientific method to the challenge of continuously improving an organization's software processes and products. The Goal-Question-Metric approach recognizes that "improvement" requires metrics, but that every organization has its...

In an attempt to understand the significance of endothelin-1 (ET-1) and vasoactive intestinal contractor (VIC)/ET-2 peptides in organs during perinatal development, we performed quantitative analysis of ET-1 and VIC gene expression in mouse organs obtained from embryos at days 14 and 17 (E-14 and E-17) of pregnancy, neonates at days 0, 1, 3 and 7 after birth (N-0, -1, -3 and -7), and adult mice...

School of Plant Sciences, University of Tasmania, Hobart, Tas. 7000, Australia, School of Botany, The University of Melbourne, Vic. 3010, Australia, National Herbarium of Victoria, Royal Botanic Gardens Melbourne, Vic. 3141, Australia, Museum and Art Gallery Northern Territory, Department of Natural Resources, Environment, the Arts and Sport, GPO Box 4646, Darwin, NT 0801, Australia, School of ...

The structure and energetics of the simplest Vic-disulfoxide CH3S(O)S(O)CH3 and its key isomers are reported. Computational methods include a CASSCF[2,2] treatment with a large basis set on sulfur and oxygen, followed by multireference MP2 refinement, and also the hybrid density functional B3LYP. Calculations at the G3 level were also carried out. In contrast to previous reports, a weak bond do...

Transmission of mycoviruses that attenuate virulence (hypovirulence) of pathogenic fungi is restricted by allorecognition systems operating in their fungal hosts. We report the use of systematic molecular gene disruption and classical genetics for engineering fungal hosts with superior virus transmission capabilities. Four of five diallelic virus-restricting allorecognition [vegetative incompat...

  Objective(s): Nowadays, cancer is an important public health problem in all countries. Limitations of current chemotherapy for neoplastic diseases such as severe adverse reactions and tumor resistance to the chemotherapeutic drugs have been led to a temptation for focusing on the discovery and development of new compounds with potential anticancer activity.   Materials and Metho...

Staging in bipolar disorder: one step closer to precision psychiatry Brisa S. Fernandes, Michael Berk IMPACT Strategic Research Centre and Barwon Health, School of Medicine, Deakin University, Geelong, VIC, Australia. Laboratório das Proteı́nas Ligantes do Cálcio no Sistema Nervoso Central, Departamento de Bioquı́mica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. D...

Prior research has argued that use of optional properties in conceptual models results in loss of information about the semantics of the domains represented by the models. Empirical research undertaken to date supports this argument. Nevertheless, no systematic analysis has been done of whether use of optional properties is always problematic. Furthermore, prior empirical research might have de...

Two alleles for viomycin-capreomycin resistance (vic) in Mycobacterium smegmatis affect ribosome structures. One (vicA) affects a component of 50S subunits and the other (vicB) affects a component of 30S subunits. The locus for neomycin-kanamycin resistance (nek), which is linked to vicA and vicB, affects a component of 30S subunits. Although the erythromycin resistance locus (ery) is linked to...