The Rockefeller University Press $30.00 J. Cell Biol. Vol. 205 No. 1 113–126 www.jcb.org/cgi/doi/10.1083/jcb.201312072 JCB 113 Correspondence to Gerald R.V. Hammond: [email protected] Abbreviations used in this paper: ANOVA, analysis of variance; FKBP, FK506 binding protein; FRB, FKBP12-rapamycin binding; iRFP, infra-RFP; nMDP, normalized mean deviation product; OSBP, oxysterol binding pro...

Correspondence to Britta Engelhardt: [email protected] Abbreviations used in this paper: AJ, adherens junction; BBB, blood–brain barrier; BCSFB, blood–cerebrospinal fluid barrier; CCM, cerebral cavernous malformation; CNS, central nervous system; E-cadherin, epithelial cadherin; EAE, experimental autoimmune encephalomyelitis; Ig, immunoglobulin; MS, multiple sclerosis; RA, retinoic acid; Shh,...

The thyroid hormones (THs) L-thyroxine (T4) and L-triiodothyronine (T3) have a profound influence on the development and maturation of the mammalian brain, both before and after birth. Any impairment in the supply of THs to the developing nervous system leads to severe and irreversible changes in both the overall architecture and functions of the brain and causes, in humans, neurological and mo...

The molecular signals driving tendon development are not fully identified. We have undertaken a transcriptome analysis of mouse limb tendon cells that were isolated at different stages of development based on scleraxis (Scx) expression. Microarray comparisons allowed us to establish a list of genes regulated in tendon cells during mouse limb development. Bioinformatics analysis of the tendon tr...

Extracellular a-synuclein has been proposed as a crucial mechanism for induction of pathological aggregate formation in previously healthy cells. In vitro, extracellular a-synuclein is partially associated with exosomal vesicles. Recently, we have provided evidence that exosomal a-synuclein is present in the central nervous system in vivo. We hypothesized that exosomal a-synuclein species from ...

Excitation of tert-butylnitrite into the first and second UV absorption bands leads to efficient dissociation into the fragment radicals NO and tert-butoxy in their electronic ground states P and E, respectively. Velocity distributions and angular anisotropies for the NO fragment in several hundred rotational and vibrational quantum states were obtained by velocity-map imaging and the recently ...

The precise excitability regulation of neuronal circuits in the primary motor cortex is central to the successful and fluent production of speech. Our question was whether the involuntary execution of undesirable movements, e.g. stuttering, is linked to an insufficient excitability tuning of neural populations in the orofacial region of the primary motor cortex. We determined the speechrelated ...

Methods and Results-—Male Sprague–Dawley rats were assigned randomly to the following groups: 5/6 nephrectomy (5/6Nx) with vehicle, 5/6Nx with AST-120, sham procedure with vehicle, and sham procedure with AST-120. Vehicle and AST-120 were administered for 4 weeks. Serum levels of IS were significantly increased in 5/6Nx groups. Expression of malondialdehyde, an indicator of oxidative stress, wa...

Rab18 is one of the most highly conserved Rab GTPase regulators of membrane traffic being present in the last eukaryotic common ancestor of both the plant and animal kingdoms (Elias et al., 2012; Klöpper et al., 2012). A defined biological function has remained elusive, partly because it was lost in the budding yeast lineage used for the genetic screens for regulators of membrane traffic. Rab18...