Loss of function of the RNA helicase maleless (MLE) in Drosophila melanogaster leads to male-specific lethality due to a failure of X chromosome dosage compensation. MLE is presumably involved in incorporating the non-coding roX RNA into the dosage compensation complex (DCC), which is an essential but poorly understood requirement for faithful targeting of the complex to the X chromosome. Seque...

Analytic expressions for the first order bias and second order covariance of a general maximum likelihood estimate (MLE) are presented. These expressions are used to determine general analytic conditions on sample size, or signal-to-noise ratio (SNR), that are necessary for a MLE to become asymptotically unbiased and attain minimum variance as expressed by the Cramer-Rao lower bound (CRLB). The...

• In this paper, we study the asymptotic properties of the maximum likelihood estimator (MLE) in COGARCH(1,1) models driven by Lévy processes as proposed by Maller et al. ([13]). We show that the MLE is consistent and asymptotically normal under some conditions relevant to the moments of the driving Lévy process and the sampling scheme.

In this paper we consider the problem of testing (a) sphericity and (b) intraclass covariance structure under a Growth Curve model. The maximum likelihood estimator (MLE) for the mean in a Growth Curve model is a weighted estimator with the inverse of the sample covariance matrix which is unstable for large p close to N and singular for p larger than N . The MLE for the covariance matrix is bas...

In modeling the rate of return associated with financial instruments, common probability distributions include the lognormal, gamma, and Weibull distributions. Furthermore, the method of maximum likelihood is widely used to estimate the unknown parameters of distributions due to the highly desirable properties of maximum likelihood estimators (MLEs). These properties include asymptotic unbiased...

In wood engineering, lower quantile estimation is vital to the safety of the construction with wood materials. In this thesis, we will first study the censored Weibull maximum likelihood estimate (MLE) of the lower quantile as in the current industrial standard D5457 (ASTM, 2004a) from a statistical point of view. According to our simulations, the lower quantile estimated by the censored Weibul...

The embedding of time series provides a valuable, and sometimes indispensable, tool in order to analyze the dynamical properties of a chaotic system. To this purpose, the choice of the embedding dimension and lag is decisive. The scientific literature describes several methods for selecting the most appropriate parameter pairs. Unfortunately, no conclusive criterion to decide which method – and...

Horizontal transmission has been well documented as a major mechanism for the dissemination of mariner-like elements (MLEs) among species. Less well understood are mechanisms that limit vertical transmission of MLEs resulting in the "spotty" or discontinuous distribution observed in closely related species. In this article we present evidence that the genome of the common ancestor of the melano...

BACKGROUND We report on the natural history of lower urinary tract symptoms (LUTS) and urinary continence in patients with median lobe enlargement (MLE) after robotic radical prostatectomy (RP). METHODS Patients treated with RP from October 2008 to March 2012 completed American Urological Association symptom index (AUAI) and continence assessments at the preoperative visit and each postoperat...

In simple random sampling, there is an equal chance of selection for each unit in the population. However, there are some practical situations where this might not be ideal. We consider the case of length-biased sampling, whereby the chance of selection of a unit is proportional to the length of the unit, by which the length-biased density is defined. Specifically we consider the case of a cont...