Last level caches (LLCs) account for a substantial fraction of the area and power budget in many modern processors. Two recent trends — dwindling die yield that falls off sharply with larger chips and increasing static power — make a strong case for a fresh look at LLC design. Inclusive caches are particularly interesting because many commercially successful processors use inclusion to ease coh...

Recent research has proposed having a die-stacked last-level cache (LLC) to overcome the memory wall. Lately, spin-transfer-torque random access memory (STT-RAM) caches have received attention, since they provide improved energy efficiency compared with DRAM caches. However, recently proposed STT-RAM cache architectures unnecessarily dissipate energy by fetching unneeded cache lines (CLs) into ...

Tumor necrosis factor-alpha (TNF) binds to two receptors: TNFR1/p55-cytotoxic and TNFR2/p75-pro-survival. We have shown that tumor growth in p75 knockout (KO) mice was decreased more than 2-fold in Lewis lung carcinoma (LLCs). We hypothesized that selective blocking of TNFR2/p75 LLCs may sensitize them to TNF-induced apoptosis and affect the tumor growth. We implanted intact and p75 knockdown (...

Forskolin, a naturally occurring activator of adenylate cyclase, inhibits total and high-affinity cyclic AMP phosphodiesterase activity in soluble and particulate fractions of cultured LLC-PK1 renal epithelial cells. The naturally occurring forskolin analogue 1,9-dideoxyforskolin, which does not stimulate adenylate cyclase activity, is a more potent inhibitor of cyclic AMP phosphodiesterase act...

As the number of cores in chip multi-processor systems increases, the contention over shared last-level cache (LLC) resources increases, thus making LLC optimization critical, especially for embedded systems with strict area/energy/power constraints. We propose cache partitioning with partial sharing (CaPPS), which reduces LLC contention using cache partitioning and improves utilization with sh...

Ultra high thread-level parallelism in modern GPUs usually introduces numerous memory requests simultaneously. So there are always plenty of memory requests waiting at each bank of the shared LLC (L2 in this paper) and global memory. For global memory, various schedulers have already been developed to adjust the request sequence. But we find few work has ever focused on the service sequence on ...

In a typical commercial multi-core processor, the last level cache (LLC) is shared by two or more cores. Existing studies have shown that the shared LLC is beneficial to concurrent query processes with commonly shared data sets. However, the shared LLC can also be a performance bottleneck to concurrent queries, each of which has private data structures, such as a hash table for the widely used ...

Last level caches (LLC) play an important role in current and future chip multiprocessors, since they constitute the last opportunity to avoid expensive off-chip accesses. In a tiled CMP, the LLC is typically shared by all cores but physically distributed along the chip, thus providing a global banked capacity memory with high associativity. The memory hierarchy is orchestrated through a direct...

AIMS To compare prospectively the efficacy of the Vero, LLC-MK2, MDCK, Hep-2, and MRC-5 cell lines in the isolation of the mumps virus from clinical samples by means of the shell vial method. METHODS During an epidemic outbreak of parotiditis 48 clinical samples (saliva swabs and CSF) were studied. Two vials of the Vero, LLC-MK2, MDCK, MRC-5, and Hep-2 cell lines were inoculated with 0.2 ml o...

− In this paper, small signal characteristic of a LLC resonant converter is analyzed. LLC resonant converter was been reported in many papers recently because of its simple structure, high efficiency and high switching frequency capability. In order to make practical use of this topology, understanding its small signal characteristic is essential to design the control loop. For PWM converter, s...