O zebrafish ou paulistinha (Danio rerio) são cada vez mais utilizados em pesquisas científicas incluindo a pesquisa básica e aplicada nas áreas de biomedicina, toxicologia, ciências ambientais aquicultura. No Brasil, os biotérios automatizados escassos, têm custo oneroso para fazer uso do modelo animal necessárias adaptações criação manutenção da espécie. Deve existir compreensão que as devem r...

Cell signaling is determined partially by the localization and abundance of proteins. Dystroglycan integrin are both transmembrane receptors that connect cytoskeleton inside muscle cells to extracellular matrix outside cells, maintaining proper adhesion function muscle. The position relative integrins thought be important for function. subcellular quantification these receptor proteins can at n...

mordial germ cells (PGCs) in mice and axolotls, we propose that the deletion of Nanog in species often employed as experimental models, such as frogs and teleosts (Zebrafish; Danio rerio), has been compensated by the evolution of predetermined germ cells in these organisms. Our data highlights Nanog as a major component of the gene regulatory network that governs early development in the major ...

Modeling human disease in animals is an important strategy to discover potential methods of intervention. We suggest that there is much to be gained by employing a multi-model approach that takes advantage of different animal systems used in the laboratory simultaneously. We use the example of modeling Alzheimer's disease in Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio to il...

Miller and Gerlai proposed two methods for determining shoal membership in Danio rerio, one based on momentary mean inter-individual distances and the other on post hoc analysis of the trajectories of nearest-neighbor distances. We propose a method based on momentary nearest-neighbor distances and compare the three methods using simulation. In general, our method yielded results that were more ...

mordial germ cells (PGCs) in mice and axolotls, we propose that the deletion of Nanog in species often employed as experimental models, such as frogs and teleosts (Zebrafish; Danio rerio), has been compensated by the evolution of predetermined germ cells in these organisms. Our data highlights Nanog as a major component of the gene regulatory network that governs early development in the major ...

The zebrafish (Danio rerio) has been widely utilised for the study of developmental biology, which has lead to the evolution of sophisticated cellular and molecular approaches. More recently, the rapid progress of various zebrafish genomic infrastructure initiatives is facilitating the development of zebrafish models of human disease. This review aims to describe several representative examples...

Bu çalışmanın amacı, tiazolidin’in (Tiazolidin-4-karboksilik asit (4S)-2- (4-hidroksi-3-metoksifenil) zebra balığı (Danio rerio) solungaç ve karaciğer dokusunda asetilkolinesteraz enzim (AChE) aktivitesi total protein (TP) düzeyleri üzerindeki etkilerinin araştırılmasıdır. Zebra balıkları 0,2 ppm, 0,4 ppm 0,6 farklı dozlarına 96 saat süreyle maruz bırakılmıştır. AChE dokusunda, doz gruplarında,...

In recent years, it has become clear that all of the organisms on the Earth are related to each other in ways that can be documented by molecular sequence comparison. In this review, we focus on the evolutionary relationships among the proteins of the eukaryotes, especially those that allow inference of function from one species to another. Data and illustrations are derived from specific compa...

The internal brain dynamics that link sensation and action are arguably better studied during natural animal behaviors. Here, we report on a novel volume imaging and 3D tracking technique that monitors whole brain neural activity in freely swimming larval zebrafish (Danio rerio). We demonstrated the capability of our system through functional imaging of neural activity during visually evoked an...