Abstract We have identified an pan-anti-MHC-I mAb (M1/42), which blocks the interaction of NK cell inhibitory receptors (Ly-49 antigens) with MHC-I, but does not inhibit antigen presentation by MHC-I. Administration M1/42 in vivo markedly activated IFNg-producing cells. cell-derived IFNg stimulated APC to produce IL-12/-15/-18 cytokine cascades that further drove proliferation cells and memory ...

Abstract T cell immunity to viruses and cancers is crucially dependent on the surface display of major histocompatibility complex class I (MHC-I) molecules selectively loaded with high affinity peptides. Peptide loading occurs in ER within a multimolecular assembly known as peptide (PLC). A critical component PLC tapasin, 45 kDa membrane glycoprotein whose absence expression stability MHC-I are...

The coordination difference between the unprotonated tertiary structures of a native (Tax) peptide and a number of its variants - all peptides presented by HLA-A201 and bound to the human A6 T cell receptor-was discovered to constitute a metric of pMHC-TCR functional avidity. Moreover, increasing coordination deviations from the index were found to flag correspondingly weakening immunological o...

Autophagy-related (ATG) gene products regulate macroautophagy, LC3-associated phagocytosis (LAP) and LC3-dependent extracellular vesicle loading secretion (LDELS). These processes also influence antigen processing for presentation on major histocompatibility complex (MHC) molecules to T cells. Here, I summarize how these different pathways use the macroautophagy machinery, contribute MHC class ...

abstract: the extreme polymorphism in mhc b-f genes enables the chickens to recognize enormous numbers of foreign peptides to trigger an immune reaction. study of this genetic resources is very important and it is essential to avoid the loss of genetic variability. genetic polymorphism among arian strain, a endogenous broiler chickens in iran, was investigated. in this study pcr-sscp was carrie...