Jenni, Lukas, Susanne Jenni-Eiermann, Fernando Spina, and Hubert Schwabl. Regulation of protein breakdown and adrenocortical response to stress in birds during migratory flight. Am J Physiol Regulatory Integrative Comp Physiol 278: R1182–R1189, 2000.— During long-term fasting at rest, protein utilization is maintained at low levels until it increases at a threshold adiposity. This study examine...

JACQUES A. DURR,1,2 JOHANNES HENSEN,3 TOBIAS EHNIS,4 AND MARY S. BLANKENSHIP5 (With the Technical Assistance of C. Klein) 1Division of Nephrology, Department of Veterans Affairs Medical Center, Bay Pines 33744; 2Department of Medicine, University of South Florida College of Medicine, Tampa 33612; 3Klinikum Hannover Nordstadt, Medizinische Klinik, Hannover 30167; 4Department of Medicine IV, Univ...

FREDERICK E. ALBRECHT,1,2 JING XU,1 ORSON W. MOE,3 ULRICH HOPFER,4 WILLIAM F. SIMONDS,5 JOHN ORLOWSKI,6 AND PEDRO A. JOSE1,2 1Departments of Pediatrics, and 2Physiology and Biophysics, Georgetown University Medical Center, Washington, District of Columbia 20007; 3Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75235; 4Department of Physiology,...

BRIAN J. BLYTH,1 RICHARD L. HAUGER,2,3 ROBERT H. PURDY,2,3 AND JANET A. AMICO1,4,5 1Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh 15261; 4Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh 15261; 5Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15261; 2Department of Psychiatry, University of Ca...

Wang, L. D., M. Wang, A. Todisco, E. Grand, and J. Del Valle. The human histamine H2 receptor regulates c-jun and c-fos in a differential manner. Am J Physiol Cell Physiol 278: C1246–C1255, 2000.—Previously, we demonstrated that activation of the human H2 receptor (hH2R) leads to an increase in c-fos transcription and cell proliferation. The purpose of these studies was to examine whether hH2R ...

Wang, Yan, and Yoram Rudy. Action potential propagation in inhomogeneous cardiac tissue: safety factor considerations and ionic mechanism. Am J Physiol Heart Circ Physiol 278: H1019–H1029, 2000.—Heterogeneity of myocardial structure and membrane excitability is accentuated by pathology and remodeling. In this study, a detailed model of the ventricular myocyte in a multicellular fiber was used t...

Kopp, Ulla C., Donna M. Farley, Michael Z. Cicha, and Lori A. Smith. Activation of renal mechanosensitive neurons involves bradykinin, protein kinase C, PGE2, and substance P. Am J Physiol Regulatory Integrative Comp Physiol 278: R937–R946, 2000.—Increased renal pelvic pressure or bradykinin increases afferent renal nerve activity (ARNA) via PGE2-induced release of substance P. Protein kinase C...

Individuals with REM sleep behaviour disorder are at significantly higher risk of developing Parkinson’s disease. Here we examined visual short-term memory deficits—long associated with Parkinson’s disease—in patients with REM sleep behaviour disorder without Parkinson’s disease using a novel task that measures recall precision. Visual short-term memory for sequentially presented coloured bars ...

Hoit, Brian D., Vivek J. Kadambi, Daniel A. Tramuta, Nancy Ball, Evangelia G. Kranias, and Richard A. Walsh. Influence of sarcoplasmic reticulum calcium loading on mechanical and relaxation restitution. Am. J. Physiol. Heart Circ. Physiol. 278: H958–H963, 2000.—Mechanical and relaxation restitution represent the restoration of contractile force and relaxation, respectively, in premature beats h...

Epigenetic changes are inherited alterations in DNA that affect gene expression and function without altering the DNA sequence. DNA methylation is one epigenetic process implicated in human disease that is influenced by diet. DNA methylation involves addition of a 1-C moiety to cytosine groups in DNA. Methylated genes are not transcribed or are transcribed at a reduced rate. Global under-methyl...