Epidemiological studies have suggested that consumption of green tea may decrease the risk of a variety of cancers. In addition, mushroom Ganoderma lucidum has been used for the promotion of health, longevity and treatment of cancer in traditional Chinese medicine. In the present study we show that extract from green tea (GTE) increased the anticancer effect of G. lucidum extract (GLE) on cell ...

Ganoderma lucidum is a popular herbal medicine used in China to promote health. Modern studies have disclosed that the active ingredients of Ganoderma can exhibit several effects, including antitumor effects and immunomodulation. The present study evaluated the antitumor effects of self-prepared Ganoderma extracts and spores oil, and investigated the possible underlying mechanisms by observing ...

Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, which is a popularly used traditional Chinese medicine for complementary cancer therapy. In the present study, systematic isolation, and in silico pharmacological prediction are implemented to discover potential anti-cancer active GTs from G. lucidum. Nineteen GTs, three steroids, one cerebroside, and one thym...

BACKGROUND Ganoderma lucidum (Reishi or Ling Zhi) is one of the most famous Traditional Chinese Medicines and has been widely used in the treatment of various human diseases in Asia countries. It is also a fungus with strong wood degradation ability with potential in bioenergy production. However, genes, pathways and mechanisms of these functions are still unknown. METHODOLOGY/PRINCIPAL FINDI...

The characteristic constituents of Ganoderma lucidum, such as polysaccharides, triterpenoids, nucleic acids, and small proteins, have been found and proved to have many special pharmacological properties. Mice have been used to extensively investigate the effects of G. lucidum. Experiments with mice investigating the effects of concentrates of G. lucidum have never been reported. The purpose of...

Ganoderma lucidum (G. lucidum) is a medicinal mushroom renowned in East Asia for its potential biological effects. To enable a systematic exploration of the genes associated with the various phenotypes of the fungus, the genome consortium of G. lucidum has carried out an expressed sequence tag (EST) sequencing project. Using a Sanger sequencing based approach, 47,285 ESTs were obtained from in ...

Phylogenetic relationship of Ganoderma species confining to Tamil Nadu was assessed by three molecular markers viz., internal transcribed spacer region (ITS) 1 and 2, β-tubulin and ATP synthase subunit 6 (atp6). Forty-three isolates representing 11 species of Ganoderma were identified from ITS rDNA sequence data. The nucleotide variations found in the ITS region were suitable for discriminating...