Pyrrole-imidazole (Py-Im) polyamides are nuclease-resistant novel compounds that inhibit gene expression by binding to the minor groove of DNA. A Py-Im polyamide that targets rat TGF-beta1 was designed as a gene-silencing agent for progressive renal diseases, and the distribution and the effects of this polyamide on renal injury were examined in Dahl-salt sensitive (Dahl-S) rats. For identifica...

The advancement of DNA-based bionanotechnology requires efficient strategies to functionalize DNA nanostructures in a specific manner with other biomolecules, most importantly peptides and proteins. Common DNA-functionalization methods rely on laborious and covalent conjugation between DNA and proteins or peptides. Pyrrole-imidazole (Py-Im) polyamides, based on natural minor groove DNA-binding ...

The cation, anion, and solvent in the title compound, [K(C(18)H(36)N(2)O(6))][Co(C(8)H(12))(C(16)H(10))(2)]·0.5C(5)H(12), are well separated. The pentane solvent mol-ecules are found in channels along [100] and were modeled as disordered over crystallographic inversion centers. Using the mid-points of the coordinated olefins, the angle between the C(py)/C(py)-Co-C(py)/C(py) and the C(cod)/C(cod...

Abstract It is generally accepted that some trace organic contaminants (TrOCs) pass through the wastewater treatment process without being properly treated and find their way into waterbodies. These molecules can also be concentrated within biosolids (BS) adsorption. The presence of TrOCs in BS, which are then commonly used as soil amendments agriculture, may affect plant growth viability. pote...

The combined use of di-2-pyridyl ketone ((py)2CO) with various diols in Mn cluster chemistry has afforded five new compounds, namely, [Mn11O2(OH)2{(py)2CO2}5(pd)(MeCO2)3(N3)3(NO3)2(DMF)4](NO3)∙2DMF∙H2O (1∙2DMF∙H2O), [Mn11O2(OH)2{(py)2CO2}5(mpd)(MeCO2)3(N3)3(NO3)2(DMF)4](NO3) (2), [Mn12O4(OH)2{(py)2CO2}4(mpd)2(Me3CCO2)4(NO3)4(H2O)6](NO3)2∙2MeCN (3∙2MeCN), [Mn4(OMe)2{(py)2C(OMe)O}2(2-hp)2(NO3)2(D...

Using ligands based on either an acetylacetonate or a dipyrrin moiety appended with pyridyl groups, a series of novel heteroleptic copper(II) and cobalt(III) complexes combining both chelate units such as (acacpy(2))Cu(dpm-py) and (acacpy(2))Co(dpm-py)(2) (acacpy(2) = 1,3-bis(4-pyridyl)-1,3-propanedionate; dpm-py = 5-(4-pyridyl)dipyrrin) have been prepared and fully characterized. These two com...

The incidence and determinants of severe morbidity recurrence in sub-Saharan African HIV-infected adults on antiretroviral therapy (ART) have never been reported. In a prospective cohort study of HIV-infected adults in Abidjan the association of severe morbidity occurrence and recurrence with follow-up CD4 counts and ART on/off status was analyzed by means of multivariate failure analysis for r...

The property that describes the neuron's preferred response to inputs of injected current is called resonance. To produce resonance, a cell must have two requirements: a low-pass filter (attenuates high frequencies) and a high-pass filter (attenuates low frequencies). The neuron whose resonance frequency we wish to determine is the PY neuron of the STNS (stomatogastric nervous system) of Cancer...

The aim of this study was to test the genotypes effect of DGAT1 gene on breeding value in Iranian Holstein milk production traits. For this purpose, 103 semen samples of registered bulls were collected and then genotyped for partial region of DGAT1 gene. The studied traits were milk yield (MY), fat yield (FY), protein yield (PY), fat percentage (FP) and protein percentage (PP). First lactation ...

BACKGROUND The suitability of populations of sexually active women in Madibeng (North-West Province) and Mbekweni (Western Cape), South Africa, for a Phase III vaginal microbicide trial was evaluated. METHODS Sexually active women 18-35 years not known to be HIV-positive or pregnant were tested cross-sectionally to determine HIV and pregnancy prevalence (798 in Madibeng and 800 in Mbekweni). ...