Neurotransmitter release depends critically on Munc18-1, Munc13, the Ca(2+) sensor synaptotagmin-1, and the soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptors (SNAREs) syntaxin-1, synaptobrevin, and SNAP-25. In vitro reconstitutions have shown that syntaxin-1-SNAP-25 liposomes fuse efficiently with synaptobrevin liposomes in the presence of synaptotagmin-1-Ca(2+...

SNARE proteins are required for vesicle docking and fusion in eukaryotic cells in processes as diverse as homotypic membrane fusion and synaptic vesicle exocytosis [SNARE stands for SNAP receptor, where SNAP is soluble NSF attachment protein]. The SNARE proteins syntaxin 4 and vesicle-associated membrane protein (VAMP) 2/3 also participate in the insulin-stimulated translocation of GLUT4 from i...

objectives: nowadays, snap-fits are used in the automotive industry as a proper alternative for mechanical joints, cabling joints, and car interior lining joints. due to the special form of these joints, which are assembled manually, the contact area between snap-fits and the worker's fingertips can be too small. this can cause skin pain on the worker's fingertips. therefore, an ergonomic study...

OBJECTIVE We examined the predictive power of the self-harm subscale of the Schedule for Nonadaptive and Adaptive Personality (SNAP) to identify suicide attempters in the Collaborative Longitudinal Study of Personality Disorders (CLPS). METHOD The SNAP, a self-report personality inventory, was administered to 733 CLPS participants at baseline, of whom 701 (96%) had at least 6 months of follow...

مقدمه: هدف پژوهش حاضر بررسی تاثیر درمان ترکیبی مواجهه همراه با بازداری از پاسخ و آموزش رفتاری والدین بر نشانگان وسواسی-جبری در کودکان 4 تا 8 ساله با اختلال همبودی وسواسی-جبری و بی اعتنایی مقابله ای بود.روش کار: در این پژوهش از بین کودکان 4 تا 8 ساله شهر خوانسار سه کودک، یک دختر 5/7 ساله و دو پسر 6 و 7 ساله که بر اساس ملاک های dsm-5 و پرسش نامه های وسواس ییل-براون و آزمون snap-iv فرم والدین که د...

Background. Serum bile acids (SBA) are used as a routine screening tool of liver function in dogs. Serum samples are usually shipped to a referral laboratory for quantitative analysis with an enzymatic chemistry analyzer. The canine SNAP Bile Acids Test (SNAP-BAT) provides an immediate, semi-quantitative measurement of bile acid concentrations in-house. With the SNAP-BAT, bile acids concentrati...

The neuronal N-ethylmaleimide-sensitive-factor-attachment-protein receptor (SNARE) proteins 25-kDa synaptosomal protein (SNAP-25), syntaxin 1 and synaptobrevin 2 interact to form the intermembrane SNARE complex, which mediates docking and fusion of synaptic vesicles with the plasma membrane. Assembly of the SNARE complex is accompanied by conformational changes, especially in SNAP-25. SNAP-25 i...