MAN1 is a vertebrate nuclear inner membrane protein that inhibits Smad signaling downstream of TGF . MAN1 has an exposed LEM-domain-containing Nterminal region (‘MAN1-N’), two transmembrane domains and an exposed Cterminal domain (‘MAN1-C’). Many regions of human MAN1 are homologous to emerin, a LEM-domain nuclear protein, loss of which causes Emery-Dreifuss muscular dystrophy (EDMD). To test t...

Quality and sustainable tourism is one of the drivers in new economic sector, creating attractions superior products that are interest to international market world buyers. This study aims at investigating development efforts through annual execution Bali Beyond Travel Fair (BBTF) Arts Festival (BAF) which will have an impact on local communities actors. uses interpretative qualitative analysis...

Optical properties of BaF2 single crystals doped with Yb3+ and Er ions are studied. The highest ?UC value 10.0% was demonstrated for the BaF2:Er3+ (2 mol%) /Yb3+ (3 sample under 490 W cm?2 976 nm excitation.

The emergence of benchtop sequencers has made clinical genetic testing using next-generation sequencing more feasible. Ion Torrent's PGM™ is one such benchtop sequencer that shows clinical promise in detecting single nucleotide variations (SNVs) and microindel variations (indels). However, the large number of false positive indels caused by the high frequency of homopolymer sequencing errors ha...

When HIV infects a T lymphocyte, it first inserts a copy of its genome into the cell’s DNA. This inserted virus, called a provirus, then races to make as many new viruses as possible before its host cell dies. But in a few infected cells, HIV does not immediately turn its host into a viral factory. Instead, the provirus is carried around in the DNA of the cell as a transcriptionally silent—or l...

The SWI/SNF family of chromatin-remodeling complexes facilitates gene activation by assisting transcription machinery to gain access to targets in chromatin. This family includes BAF (also called hSWI/SNF-A) and PBAF (hSWI/SNF-B) from humans and SWI/SNF and Rsc from Saccharomyces cerevisiae. However, the relationship between the human and yeast complexes is unclear because all human subunits pu...

Research Roundup Research Roundup for example, two nearby cells can somehow tell which one is closer to the equator (middle) of the eye, and specify the R3 (equatorial) and R4 (polar) fates, accordingly. " This is one of the great puzzles of PCP, " says Simon. " The cells are reading the gradient rather than the absolute values, and sensing the smallest differences. " For that process to have a...