Buprenorphine is a potent semisynthetic opioid analgesic that is widely used to treat moderate to severe pain. Since 2001, it has been available in several European countries in a transdermal delivery system (TDS), and it was approved for use in the United States in 2010. We report 3 cases of allergic contact dermatitis caused by a TDS containing buprenorphine, as verified by a positive patch t...

The time domain synchronous orthogonal frequency division multiplex (TDS-OFDM) modulation scheme has recently been proposed in a new digital television (DTV) system. The European DTV standard DVB-T, on the other hand, uses the cyclic prefix (CP) OFDM modulation. In this paper, TDS-OFDM and CP-OFDM for nonergodic broadcast inter-symbol-interference channels are compared from an information theor...

INTRODUCTION A slight decrease in blood testosterone level in men is a physiological state associated with the aging. The aim of our study was to evaluate the occurrence of hormone and metabolic disorders, as well as the immunolocalization and immunoexpression of androgen receptors (AR) and estrogen-alpha receptors (ERa) in the prostates of men with benign prostatic hyperplasia (BPH) and coexis...

Linear time-invariant time-delay systems (LTI-TDS) constitute a widespread family of plants and systems, not only limited to industrial ones. They can be represented by Laplace transfer functions in the form of fractions of so-called quasipolynomials. Direct controller design for LTI-TDS based on such models is mostly rather intricate. Many approaches require a rational approximation of the tra...