Hypericum perforatum L. (Hypericaceae) is one of the medicinal plants whose value has increased rapidly in recent years. It especially popular for its use treatment mild and moderate depression, as well skin diseases, internal external inflammatory wounds, neurological disorders, metabolism-disrupting effects free radicals. Besides, it shows inhibitory against different kinds microorganisms suc...

Monoamine oxidase (MAO) catalyzes the oxidative deamination of amines and neurotransmitters and is involved in mood disorders, depression, oxidative stress, and adverse pharmacological reactions. This work studies the inhibition of human MAO-A by Hypericum perforatum, Peganum harmala, and Lepidium meyenii, which are reported to improve and affect mood and mental conditions. Subsequently, the an...

OBJECTIVE Hypericum perforatum (St. John's Wort) has long been used in traditional medicine to treat a variety of internal and external ailments. The present study was done to evaluate the immumodulatory potentials of the hydroalcoholic extract of H. perforatum. MATERIALS AND METHODS Twenty male BALB/c-mice were randomly allocated in two equal groups and immunized with sheep red blood cells (...

The pharmacological approach to the treatment of depression includes a long-term employment of antidepressants, either in the form of monotherapy or as a combination of several antidepressants with various mechanisms of action. Hypericum perforatum L. (St. John's wort) is the only natural antidepressant. Several constituents of the extract, such as hypericin and hyperforin, seem to be important...

BACKGROUND/OBJECTIVES This study was conducted to assess the potential of St. John's Wort (Hypericum perforatum) to prevent obesity and abnormalities in lipid metabolism induced by ovariectomy in a rat model without stimulatory activity on uterus. MATERIALS/METHODS Ovariectomized (OVX) rats were treated for 6 weeks with 70% ethanol extracts of Hypericum perforatum [HPEs: whole plant (WHPE) an...

John Hick has used revolutionary metaphors in recommending his pluralistic philosophy of religions. To turn from a focus on the particulars of one’s home religion to a focus on the universally available Real is, he famously says, a Copernican “revolution” in religious thought. Hick says that those religious adherents who abandon the traditional positions of exclusivism or inclusivism, positions...

BACKGROUND Mastitis reduces milk yield and alters milk composition. Antibiotics are widely used in the treatment of the disease. However, this widespread use of antibiotics causes both antibiotic residues in milks and antibiotic resistance developed in bacteria. Today's researches are focused on discovering and using new antibiotics against bacteria. OBJECTIVE The aim of this work was to disc...

CYP: cytochrome P INTRODUCTION Pemphigus foliaceus is a rare autoimmune bullous dermatosis that can be induced by drugs, with variable duration lasting between several weeks and months. Erythematous scaly patches develop on the scalp, face, neck or chest. The use of oral or topical herbal supplements to improve health has increased in the last decades. These preparations may trigger multiple ad...