The effect of the ionic products of Bioglass 45S5 dissolution on the gene-expression profile of human osteoblasts was investigated by cDNA microarray analysis of 1,176 genes. Treatment with the ionic products of Bioglass 45S5 dissolution increased the levels of 60 transcripts twofold or more and reduced the levels of five transcripts to one-half or less than in control. Markedly up-regulated ge...

Molecular dynamics simulations of Na(+)/H(+)-exchanged 45S5 Bioglass® models reveal that a large fraction of the hydroxyl groups introduced into the proton-exchanged, hydrated glass structure do not initially form covalent bonds with Si and P network formers but remain free and stabilised by the modifier metal cations, whereas substantial Si-OH and P-OH bonding is observed only at higher Na(+)/...

introduction: an ideal intracanal medicament should be able to eliminate any remaining intracanal microorganism. the aim of this study was to compare the antimicrobial effects of bioglass 45s5 with calcium hydroxide on enterococcus ( e ) faecalis in-vitro . materials & methods: direct exposure test (det) was used to evaluate the antimicrobial effect of bioglass 45s5, calcium hydroxide and norma...

objective: bioactive glass 45s5 is a surface reactive glass-ceramic biomaterial, developed in 1969. bag 45s5 with particle size of 20-60 nm has the ability of bone regeneration, broad spectrum antibacterial effect, repairs and replaces diseased or damaged bone. the aim of this study was to evaluate the antibacterial activity and determine mic and mbc values of nano-bag45s5 on streptococcus muta...

in order to increase the life span of implants, coatings such as bioglass are applied on implants' surfaces to prevent their corrosion in biological fluids. in this research, 45s5 bioglass coatings were applied on 316l stainless steel substrate by sol- gel method and coating's properties were examined by different analyses. according to the xrd results, an amorphous compound containing na2ca2si...

Abstract Bioglass 45S5 is the most widely used bioactive glass composition in orthopedics to regenerate bone tissue. Although its reactions vitro and vivo are well established, impact of local environment on dissolution behavior dynamic not fully understood. Here, we show that ion concentrations released from into Tris‐buffer solution simulated body fluid (SBF) a cascade system three reactors s...