In this study, an optimization model is proposed to design a Global Supply Chain (GSC) for a medical device manufacturer under disruption in the presence of pre-existing competitors and price inelasticity of demand. Therefore, static competition between the distributors’ facilities to more efficiently gain a further share in market of Economic Cooperation Organization trade agreement (ECOTA) is...

Glioblastomas are the most frequent and aggressive intracranial neoplasms in humans, and despite advances and the introduction of the alkylating agent temozolomide in therapy have improved patient survival, resistance mechanisms limit benefits. Recent studies support that glioblastoma stem-like cells (GSCs), a cell subpopulation within the tumour, are involved in the aberrant expansion and ther...

Through a newly established Research Coordination Network for the Genomic Standards Consortium (RCN4GSC), the GSC will continue its leadership in establishing and integrating genomic standards through community-based efforts. These efforts, undertaken in the context of genomic and metagenomic research aim to ensure the electronic capture of all genomic data and to facilitate the achievement of ...

This report summarizes the proceedings of the "Metagenomics, Metadata and Meta-analysis" (M3) Special Interest Group (SIG) meeting held at the Intelligent Systems for Molecular Biology 2009 conference. The Genomic Standards Consortium (GSC) hosted this meeting to explore the bottlenecks and emerging solutions for obtaining biological insights through large-scale comparative analysis of metageno...

The straylight contamination due to the Galactic emission (GSC, Galaxy Straylight Contamination) entering at large angles from the antenna centre direction may be one of the most critical sources of systematic effects in observations of the cosmic microwave background (CMB) anisotropies by future satellite missions like Planck and MAP. For the Low Frequency Instrument (LFI), this effect is expe...

OBJECTIVE: Sleep disruption is common in widow(er)s. The objective of this study was to characterize the sleep of Spousally Bereaved (SB) seniors (60y+) studied within 4-19 months of being widowed. METHOD: Subjective (PSQI, 2-weeks diary) and objective (2-weeks actigraphy) baseline sleep measures were obtained in 47 (38f, 9m) Spousally Bereaved (SB) seniors, 33 (25f, 8m) Good Sleeper Controls (...

In this paper, we compare low cost implementations of wideband adaptive beamformers utilising the generalised sidelobe canceller (GSC) in combination with the least-mean squares algorithms. DFT based techniques suffer from unjustified narrowband assumptions. We therefore derive and investigate an overlap-save implementation of the GSC, which offers a steady state suppression of jammers equivale...