Employment or Leadership: N.G. Morgenthaler, BRAHMS; A. Bergmann, BRAHMS. Consultant or Advisory Role: M.H. Brutsche, advisory boards for Pfizer (Champix, Spiriva), GlaxoSmithKline, and Novartis; C. Mueller, BRAHMS and Abbott Laboratories. Stock Ownership: A. Bergmann, BRAHMS. Honoraria: C. Mueller, Biosite, Abbott Laboratories, Roche, BRAHMS, and Siemens. Research Funding: M.T. Maeder, Swiss S...

We consider how to break the near degeneracy between dark matter and baryonic MOdified Newtonian Dynamics (MOND). We show that the Roche Lobes of a two-body baryonic system (e.g., a globular cluster orbiting a host galaxy) are sensitive to modifications of the law of gravity. We generalise the analytical results obtained in the deep-MOND limit by Zhao (2005, astro-ph/0511713), consider in the f...

Disclosure: Prof Goldsmith has received funding from Abbvie, Astellas, Bayer, Fresenius Medical Care, Keryx, Relyps, Roche, Sandoz, Sanofi, Shire, Vifor, and ZS Pharma. Prof Mann received honoraria for serving as a speaker from Amgen, Astra, Braun, Fresenius, Gambro, Medice, Novo Nordisk, Relypsa, and Roche; received research funding from the European Union, Canadian Institutes Health Research,...

Antisense RNA probes were synthesized by in vitro transcription incubating 1 μg linearized plasmid, 2 μL 100 mM dithiothreitol (DTT), 1.3 μL NTP mixture (15.4 mM each ATP, CTP, GTP, and 10 mM UTP), 0.7 μL 10 mM digoxigenin-UTP or fluorescein-UTP (Roche Applied Science, Indianapolis, IN, USA), and 0.5 μL RNAguardTM (Amersham Biosciences, Piscataway, NJ, USA), 2 μL 10× transcription buffer, 1 μL ...

We used a mixed 454 and Illumina sequencing strategy. Genomic DNA from each House Finch strain was first nebulized and blunt-end ligated with Roche adaptors. Emulsion PCR was performed using the bulk library and these products were pyrosequenced on Roche 454 Gene Sequencer using FLX chemistry, using physical separation of isolates. Genomic DNA from the four newly sequenced poulty strains (Table...

Many of the known extrasolar planets are “hot Jupiters,” giant planets with orbital periods of just a few days. We use the observed distribution of hot Jupiters to constrain the location of its inner edge in the mass–period diagram. If we assume a slope corresponding to the classical Roche limit, then we find that the edge corresponds to a separation close to twice the Roche limit, as expected ...

Data retention by the company; complicit or complacent drug regulators. In 2009, while preparing its meta-analysis of oseltamivir, the Cochrane Acute Respiratory Infections Group found that only 40% of the assessment data had led to published reports, and that most of the data were unverifiable. With support from the British Medical Journal (BMJ), the Cochrane group lobbied Roche and EMA in ord...

BACKGROUND Enzymatic creatinine assays are routinely used in clinical laboratories to provide more accurate estimated glomerular filtration rates and to avoid a perceived lack of analytical specificity associated with picrate (Jaffe) methods. Negative interferences with the enzymatic creatinine assay, which we noted in several patients on dopamine or dobutamine, prompted our further investigati...