When using the Genetic Programming (GP) Algorithm on a diicult problem with a large set of training cases, a large population size is needed and a very large number of function-tree evaluations must be carried out. This paper describes how to reduce the number of such evaluations by selecting a small subset of the training data set on which to actually carry out the GP algorithm. Three subset s...

In vitro evaluation of P-glycoprotein (P-gp) inhibitory potential is now a regulatory issue during drug development, in order to predict clinical inhibition of P-gp and subsequent drug-drug interactions. Assays for this purpose, commonly based on P-gp-expressing cell lines and digoxin as a reference P-gp substrate probe, unfortunately exhibit high variability, raising thus the question of devel...

Genetic programming (GP) is one of the computer algorithms in the family of evolutionary-computational methods, which have been shown to provide reliable solutions to complex optimization problems. The genetic programming under discussion in this work relies on tree-like building blocks, and thus supports process modeling with varying structure. In this paper the systems containing amino ac...

Recent studies showed that P-glycoprotein (P-gp) increases the portal bioavailability (FG) of loperamide by sparing its intestinal first-pass metabolism. Loperamide is a drug whose oral absorption is strongly attenuated by intestinal P-gp-mediated efflux and first-pass metabolism by cytochrome P450 3A (CYP3A). Here the effect of the interplay of P-gp and Cyp3a in modulating intestinal first-pas...

to study the anticoccidial and antioxidant effects of garlic powder (gp) and total sulfur amino acid (tsaa) on growth performance, faecal oocyst output, oxidative stress indicators and antioxidant status markers in broiler chickens, a 2 × 2 × 2 splitplot-factorial arrangement of treatments was used. a total of 480-day-old male broiler chickens were equally assigned to two plots. two hundred for...

Truncated sharp crested weirs are used to measure flow rate and control upstream water surface in irrigation canals and laboratory flumes. The main advantages of such weirs are ease of construction and capability of measuring a wide range of flows with sufficient accuracy. Artificial neural networks (ANNs) and genetic programming (GP) have recently been used for estimation of hydraulic data. In...

Platelet glycoproteins (GP) IIb and IIIa exist as noncovalently associated Ca++-dependent heterodimer complexes within the platelet membrane and express the major platelet alloantigens Leka (Baka) and PIA1 (Zwa), which are genetic markers of GP IIb and GP IIIa, respectively. Since heterodimers immunologically related to platelet GP IIb/IIIa have been identified in a number of nucleated cell typ...

Platelet membrane glycoproteins (GP) IIb and IIIa form a Ca2+-dependent, heterodimer complex (GP IIb-IIIa) in detergent solution. To determine whether these glycoproteins were complexed or dissociated in intact human platelets, 125I-labeled whole platelets were lysed with an EDTA/Triton X-100 buffer, which stabilized both the complexed and dissociated forms of GP IIb and GP IIIa. The percentage...

We explicitly carry out the symplectic quantization of a family multifield generalized Proca (GP) electrodynamics theories. In process, we provide an independent derivation so-called secondary constraint enforcing relations---consistency conditions that significantly restrict allowed interactions in settings already at classical level. Additionally, unveil existence quantum consistency conditio...