In the last few years many new reaction routes and intermediates have been discovered in the mechanism of the Belousov-Zhabotinsky (BZ) reaction with the aid of high performance liquid chromatography (HPLC). These previous HPLC studies, however, were limited to the Ce(4+)-organic substrate (malonic or bromomalonic acid) systems only. Very recently some measurements were made on a cerium catalys...

OBJECTIVE The objective of this study was to analyze the effectiveness and long-term tolerability of adjuvant lacosamide (LCM) in a multicenter cohort. We aim to assess outcomes of LCM-containing antiepileptic drug (AED) combinations based upon 'mechanism of action' (MoA) and patient's clinical features. METHODS Consecutive patients commenced on LCM, with focal epilepsy were identified from t...

Metasezgisel arama algoritmalar?, birçok uygulama alan?nda farkl? optimizasyon problemlerini çözmek için yayg?n bir biçimde kullan?lmaktad?r. Özellikle, son y?llarda, karma??k etkin çözebilmek fiziksel, kimyasal veya biyolojik olaylardan esinlenilerek metasezgisel algoritma geli?tirilmi?tir. Do?adaki mart?lar?n göç ve sald?r? davran??lar?ndan ilham al?narak geli?tirilen Mart? Optimizasyon Algor...

Currently there is limited understanding, agreement, and research within the phenomena of community engagement and participation in local community festivals and events. This article aims to contribute to this growing, but limited, debate by justifying the adaption and integration of the Motivation–Opportunity–Ability (MOA) model, and proposing a combination of primary data collection and analy...

Linear and nonlinear toxicity criteria were derived for 2,3,7,8-tetrachlorodibenzo(p)dioxin (TCDD) using the recent National Toxicology Program rat cancer bioassay. Dose-response relationships were assessed for combined liver tumors based on lifetime average liver concentrations (LALCs) estimated with a toxicokinetic model. Rat LALC estimates at the 1% point of departure (POD) were obtained wit...

The newly developed Extensible Markup Language (XML) is rapidly gaining popularity. It is believed that XML will be the next standard for the WWW. XML defines a standard for exchanging data, based on an extensible mechanism that allows the user to describe the structure of documents. There is a clear resemblance between XML documents and semistructured data. The structure of XML documents can b...

Several synthetic class A peptide analogues have been shown to mimic many of the properties of human apo A-I in vitro. A new peptide [acetyl-(AspTrpLeuLysAlaPheTyrAspLysValPheGluLysPheLysGluPhePhe)-NH2; 5F], with increased amphipathicity, was administered by intraperitoneal injection, 20 microg/day for 16 weeks, to C57BL/6J mice fed an atherogenic diet. Mouse apo A-I (MoA-I) (50 microg/day) or ...

Traditional Chinese medicine (TCM) and Ayurveda have been used in humans for thousands of years [1]. While the link to a particular indication has been established in man, the mode-of-action (MOA) of the formulations is relatively unknown. In this study, we aim to understand the MOA of formulations used in traditional medicine using in silico target prediction tools, which predicts protein targ...