Adipsic diabetes insipidus (ADI) is a rare disorder. It can occur after transcranial surgery for craniopharyngeoma, suprasellar pituitary adenoma and anterior communicating artery aneurysm but also with head injury, toluene exposure and developmental disorders. It is often associated with significant hypothalamic dysfunction and complications like obesity, sleep apnea, thermoregulatory disorder...

A tensor-product higher-order space-time discontinuous-Galerkin method is extended to unstructured element shapes. The use of a tensor-product formulation is key to maintaining efficiency at high polynomial orders. The discrete system of equations arising at each space-time slab is solved using a Jacobian-free Newton-Krylov scheme. An alternatingdirection-implicit (ADI) preconditioner for hexah...

In this paper we describe the 3-D Telegraph Equation (3-DTEL) with the use of Alternating Direction Implicit (ADI) method on Geranium Cadcam Cluster (GCC) with Message Passing Interface (MPI) parallel software. The algorithm is presented by the use of Single Program Multiple Data (SPMD) technique. The implementation is discussed by means of Parallel Design and Analysis with the use of Domain De...

We consider the problem of acceleration of the Alternative Directions Implicit (ADI) scheme for Dirichlet problem for biharmonic equation. The second Douglas scheme is used as the main vehicle and two full time steps are organised in a single iteration unit in which the explicit operators are arranged differently for the second step. Using an a priori estimate for the spectral radius of the ope...

This paper deals with the numerical solution of the Heston partial differential equation (PDE) that plays an important role in financial option pricing theory, Heston (1993). A feature of this time-dependent, twodimensional convection-diffusion-reaction equation is the presence of a mixed spatial-derivative term, which stems from the correlation between the two underlying stochastic processes f...

Arginine deiminase (ADI)-based arginine depletion is a novel strategy under clinical trials for the treatment of malignant melanoma with promising results. The sensitivity of melanoma to ADI treatment is based on its auxotrophy for arginine due to a lack of argininosuccinate synthetase (AS) expression, the rate-limiting enzyme for the de novo biosynthesis of arginine. We show here that AS expre...

OBJECTIVE To describe characteristics and outcomes of HIV-infected patients with Pneumocystis jirovecii pneumonia (PCP) over 2004-2011 in France, in particular in those previously enrolled (PE) in the French Hospital Database on HIV (FHDH). METHODS PE patients with an incident PCP were compared with patients with an inaugural PCP revealing HIV infection (reference). Adequate adherence to care...

This study aims to analyze Adi Hidayat's al-Qur'ān interpretation on an official YouTube channel. It ensures that the public is not exposed inferior information as use of new media interpret in digital age increases and regulation becomes more complex. Therefore, problems are inevitable. Becoming a mufassīr necessitates expertise, should adhere same rules. A qualitative virtual ethnographic app...

Argininosuccinate synthetase (ASS), a key enzyme to synthesize arginine is down regulated in many tumors including hepatocellular carcinoma (HCC). Similar to previous reports, we have found the decrease in ASS expression in poorly differentiated HCC. These ASS(-) tumors are auxotrophic for arginine. Pegylated arginine deiminase (ADI-PEG20), which degrades arginine, has shown activity in these t...