The release of signaling molecules from neurons must be regulated, to accommodate their highly polarized structure. In the developing Drosophila visual system, photoreceptor neurons secrete the epidermal growth factor receptor ligand Spitz (Spi) from their cell bodies, as well as from their axonal termini. Here we show that subcellular localization of Rhomboid proteases, which process Spi, dete...

The quality of the software development process directly affects the quality of the software product. To be successful, software development organisations must respond to changes in technology and business circumstances, and therefore software process improvement (SPI) is required. SPI activity relates to any modification that is performed to the software process in order to improve an aspect o...

The principle behind software process improvement (SPI) is that product quality is strongly influenced by the quality of the associated software process for development and maintenance. A number of SPI frameworks have evolved from this principle. However, these frameworks are comprehensive and differ in a variety of aspects, making them difficult to compare objectively and to select between for...

Poxviruses encode multiple proteins that enable them to evade host responses. Among these are serine protease inhibitors (serpins). One of the earliest serpins described, cowpox virus crmA, acts to inhibit inflammation and apoptosis. crmA homologous serpins, known as SPI-2, are conserved in rabbitpox, vaccinia and variola viruses. Here, we describe the characterization of ectromelia virus (EV) ...

Expressions for error probabilities have been derived for commonly used signal constellations such as QAM and MPSK. However, closed form expressions cannot be found for more complex signal constellations such as hexagonally packed signals. Saddle point integration (SPI) has been shown to be an efficient method of evaluating the one dimensional cumulative distribution function (CDF) of a random ...

Spi Calculus is an untyped high level modeling language for security protocols, used for formal protocols specification and verification. In this paper, a type system for the Spi Calculus and a translation function are formally defined, in order to formalize the refinement of a Spi Calculus specification into a Java implementation. The Java implementation generated by the translation function u...

A suspension-point interferometer (SPI) is an auxiliary interferometer for active vibration isolation, implemented at the suspension points of the mirrors of an interferometric gravitational wave detector. We constructed a prototype Fabry-Perot interferometer equipped with an SPI and observed vibration isolation in both the spectrum and transfer function. The noise spectrum of the main interfer...

Spi Calculus is an untyped high level modeling language for security protocols, used for formal protocols specification and verification. In this paper, a type system for the Spi Calculus and a translation function are formally defined, in order to formalize the refinement of a Spi Calculus specification into a Java implementation. Since the generated Java implementation uses a custom Java libr...

Thirty-six Salmonella enterica serovar Typhi-specific genes, absent from the Salmonella enterica serovar Typhimurium genome, that were expressed in human macrophages were identified by selective capture of transcribed sequences. These genes are located on 15 unique loci of the serovar Typhi genome, including Salmonella pathogenicity islands (SPI-7, SPI-8, and SPI-10) and bacteriophages (ST15, S...

Retinoic acid receptors (RAR) belong to the same nuclear receptor superfamily as thyroid hormone receptors (TR) that were previously shown to be modulated by dietary soy protein isolate (SPI). This study has examined the effect of dietary SPI and isoflavones (ISF) on hepatic RAR gene expression and DNA binding activity. In Expt. 1, Sprague-Dawley rats were fed diets containing 20% casein or 20%...