Pro-inflammatory immune response is usually associated with Chagas disease pathogenesis, but is also relevant to treatment effectiveness. Cross-sectional studies have suggested that this activated state may persist for years after therapeutic intervention. However, short-term longitudinal investigation has suggested that the Benznidazole treatment (Bz-treatment) leads to decreased immunological...

Trypanosoma cruzi strains from distinct geographic areas show differences in drug resistance and association between parasites genetic and treatment response has been observed. Considering that benznidazole (BZ) can reduce the parasite burden and tissues damage, even in not cured animals and individuals, the goal is to assess the drug response to BZ of T. cruzi II strains isolated from children...

Chemokines (CKs) and chemokine receptors (CKR) promote leukocyte recruitment into cardiac tissue infected by the Trypanosoma cruzi. This study investigated the long-term treatment with subantimicrobial doses of doxycycline (Dox) in association, or not, with benznidazole (Bz) on the expression of CK and CKR in cardiac tissue. Thirty mongrel dogs were infected, or not, with the Berenice-78 strain...

Bz-423 is a new benzodiazepine that has cytotoxic and cytostatic effects against a number of cell types in culture, and recent studies have shown efficacy in experimental lupus models in rodents. The present study demonstrates that treating human skin in organ culture with Bz-423 suppresses retinoid-induced epidermal hyperplasia. Bz-423 suppresses hyperplasia in organ culture at concentrations ...

OBJECTIVES The purpose of this study was to determine the pathological importance of oxidative stress-induced injurious processes in chagasic heart dysfunction. BACKGROUND Trypanosoma cruzi-induced inflammatory pathology and a feedback cycle of mitochondrial dysfunction and oxidative stress may contribute to Chagas disease. METHODS Sprague-Dawley rats were infected with T. cruzi and treated...

BACKGROUND Benzimidazoles (BZ) are a class of drugs widely used in veterinary and human medicine, creating a great selection pressure and the emergence of BZ resistance. We conducted a systematic review to assess the status of resistance and/or effectiveness reduction of BZ drugs in animal nematodes in Brazil, and make information accessible to the scientific community, as many studies are publ...

We study the evolution of matter-antimatter asymmetry ({\eta}), vorticity, and hypermagnetic field in symmetric phase early Universe, temperature range 100 GeV < T 10 TeV. assume a configuration for which includes both helical non-helical (Bz) components. Consequently, fluid vorticity can directly affect each other, manifestations we explore three scenarios. In first scenario, show that presenc...

With the $\Omega$-operators for Virasoro algebra \cite{BF} and super in \cite{CL, CLL}, we get Ovsienko-Roger superalgebras this paper then use it to classify all simple cuspidal modules $\bZ$-graded $\frac12\bZ$-graded superalgebras. By result, can easily Harish-Chandra over some related Lie superalgebras, including $N=1$ BMS$_3$ algebra, $W(2,2)$, etc.

Let K(n)∗(−) be a Morava K-theory at the prime 2. Invariant theory is used to identify K(n)∗(BA4) as a summand of K(n)∗(BZ/2 × BZ/2). Similarities with H∗(BA4;Z/2) are also discussed.

Solid-state Ln-Bz compounds, where Ln stands for trivalent lanthanides and Bz is benzoate have been synthesized. Simultaneous thermogravimetric and differential thermal analysis in a CO2 atmosphere were used to study the thermal decomposition of these compounds.