OBJECTIVE Both aging and myocardial ischemia are associated with alterations of calcium-regulating proteins. We investigated the effects of graded levels of low-flow ischemia on myocardial function and on SR Ca(2+)-ATPase (SERCA2), Na(+)-Ca2+ exchanger (NCX) and ryanodine receptor (RyR2), at mRNA and protein levels in both adult and senescent myocardium. METHODS Isolated hearts from 4 and 24 ...

1. Materials: .................................................................................................................... 2 2. Structure of PAMAM dendrimers: ............................................................................. 2 3. Instrumentation: .......................................................................................................... 2 4. Experimental condi...

Under a changing climate, harvesting management and exploiting the genotypic divergence of Egyptian clover cultivars offers biologically viable solution to sustainably boost milk productivity dairy animals. Two multi-season field trials were executed under semi-arid conditions whereby first experiment aimed assess potential (Berseem Agaiti, Anmol SB-11) for nutritional quality attributes digest...

Despite having identical cystic fibrosis transmembrane conductance regulator genotypes, individuals with DeltaF508 homozygous cystic fibrosis (CF) demonstrate significant variability in severity of pulmonary disease. This investigation used high-density oligonucleotide microarray analysis of nasal respiratory epithelium to investigate the molecular basis of phenotypic differences in CF by (1) i...

objective(s):  more than 1500 registered mutations in cystic fibrosis transmembrane regulator (cftr) gene are responsible for dysfunction of an ion channel protein and a wide spectrum of clinical manifestations in patients with cystic fibrosis (cf). this study was performed to investigate the frequency of a number of well-known cftr mutations in north eastern iranian cf patients. material and m...

11 Bronchiectasis is characterized by an abnormal permanent dilatation of bronchi with destruction of the muscles and elastic tissue1. First description of the disease was by Laennec in 18192. It was considered as an orphan disease with no definite management protocols or break through therapeutic approaches until recently3. The major studies in bronchiectasis were on CF, as it is the commonest...