The Y chromosome from certain populations of M. m. domesticus is incapable of normal testis determination in the B6 inbred strain resulting in XY hermaphrodites or XY females (XY(DOM) sex reversal). B6 consomic strains have been developed with either transient (B6-Y(AKR)) or severe (B6-Y(TIR)) XY(DOM) sex reversal. We report that a point mutation, the dominant white spotting oncogene allele, Ki...

In Drosophila, the sex of germ cells is determined by cell-autonomous and inductive signals. XY germ cells autonomously enter spermatogenesis when developing in a female host. In contrast, XX germ cells non-autonomously become spermatogenic when developing in a male host. In first instar larvae with two X chromosomes, XX germ cells enter the female or the male pathway depending on the presence ...

Laser powder bed fusion (LPBF)-manufactured Sc-Zr-modified Al–Mg alloy (Scalmalloy) has a bimodal microstructure comprising coarse grains (CGs) in the hot melt pool area and ultrafine (UFGs) along boundaries (MPBs). Owing to these microstructural features, an increase MPBs can UFGs, leading enhanced mechanical properties. However, effects of LPBF process parameters, especially laser scan strate...

A child with many symptoms of trisomy 22 syndrome is described. The child showed a 46,XY/47,XY,+22 chromosome constitution. This is the first reported case of a trisome 22 phenotype with such a mosaic karyotype.

In this paper, the logarithmically complete monotonicity results of the functions [Γ(1 + x)]y/Γ(1 + xy) and Γ(1 + y)[Γ(1 + x)]y/Γ(1 + xy) are established.

It has been known for some years that apparently female patients are sometimes found to have an XY sex chromosome complement. Morris (1953) focused attention upon the syndrome of testicular feminization in which, despite the presence of XY sex chromosomes and testes, the phenotype and secondary sexual development are female. Harnden and Stewart (1959) applied the term pure gonadal dysgenesis to...

The chiral glass behaviour of the nearest-neighbour random-bond XY spin glass in four dimensions is studied by Monte Carlo simulations. A chiral glass transition at T cg = 0.90 ± 0.05 is found by a finite-size scaling analysis of the results. The associated chiral correlation-length exponent is estimated to be ν cg = 0.6 ± 0.1 and η cg ∼ 0.25. The values for the chiral critical temperature and ...

YY super-males have rarely been detected in nature and only been artificially created in some fish species including tilapia and yellow catfish (Pelteobagrusfulvidraco), which provides a promising model for testis development and spermatogenesis. In our previous study, significant differences in morphology and miRNA expression were detected between XY and YY testis of yellow catfish. Here, sole...

OBJECTIVE Ovotesticular disorder of sexual development (DSD) is an unusual form of DSD, characterized by the coexistence of testicular and ovarian tissue in the same individual. In a subset of patients, ovotesticular DSD is caused by 46,XX/46,XY chimerism or mosaicism. To date, only a few monogenetic causes are known to be associated with XX and XY ovotesticular DSD. DESIGN AND METHODS Clinic...

Histone macroH2A1.2 and the murine heterochromatin protein 1, HP1 beta, have both been implicated in meiotic sex chromosome inactivation (MSCI) and the formation of the XY-body in male meiosis. In order to get a closer insight into the function of histone macroH2A1.2 we have investigated the localisation of macroH2A1.2 in surface spread spermatocytes from normal male mice and in oocytes of XX a...