BACKGROUND Papillon-Lefevre Syndrome (PLS) is a rare autosomal recessive disorder characterized by diffused palmoplantar keratoderma and severe periodontitis. Increased susceptibility to infections due to impairment of the immune system is considered to be involved in pathoetiology of this disease. OBJECTIVES According to the crucial function of HLA molecules in immune responses and associati...

We investigate Newton-type optimization methods for solving piecewise linear systems (PLS) with non-degenerate coefficient matrix. Such systems arise, for example, from the numerical solution of linear complementarity problem which is useful to model several learning and optimization problems. In this paper, we propose an effective damped Newton method, namely PLSDN, to find the exact solution ...

Uncovering unobserved heterogeneity is a requirement to obtain valid results when using the structural equation modeling (SEM) method with empirical data. Conventional segmentation methods usually fail in SEM since they account for the observations but not the latent variables and their relationships in the structural model. This research introduces a new segmentation approach to variance-based...

Motivated by recent critique toward partial least squares path modeling (PLS), we present a research question if the PLS method, as used currently, is at all an appropriate tool for theory testing. We briefly summarize some of the recent critique of the use of PLS in IS as a theory testing tool. Then we analyze the results of 12 PLS analyzes published in leading IS journals testing if these mod...

Partial least squares (PLS) is a widely used method for prediction in applied statistics, especially in chemometrics applications. However, PLS is not invariant or equivariant under scale transformations of the predictors, which tends to limit its scope to regressions in which the predictors are measured in the same or similar units. Cook et al. (2013) built a connect between nascent envelope m...

Model performance of the partial least squares method (PLS) alone and bagging-PLS was investigated in online near-infrared (NIR) sensor monitoring of pilot-scale extraction process in Fructus aurantii. High-performance liquid chromatography (HPLC) was used as a reference method to identify the active pharmaceutical ingredients: naringin, hesperidin and neohesperidin. Several preprocessing metho...

Projection to Latent Structures (PLS), also known as Partial Least Squares, is a method for matching objects from two heterogeneous domains. Although PLS is empirically verified effective for matching queries and documents, its scalability becomes a major hurdle for its application in real-world web search. In this paper, we study a general framework for matching heterogeneous objects, which re...

Three men were initially diagnosed as having primary lateral sclerosis (PLS), but eventually developed amyotrophic lateral sclerosis (ALS) after 7.5, 9, and at least 27 years. Non-familial ALS and PLS might be different manifestations of a single disease or constitute completely distinct entities. The clinical diagnosis of PLS predicts a median survival that is four to five times longer than in...

We propose a novel framework that combines penalization techniques with Partial Least Squares (PLS). We focus on two important applications. (1) We combine PLS with a roughness penalty to estimate high-dimensional regression problems with functional predictors and scalar response. (2) Starting with an additive model, we expand each variable in terms of a generous number of B-Spline basis functi...

This paper adds to an important aspect of Partial Least Squares (PLS) path modeling, namely the convergence of the iterative PLS path modeling algorithm. Whilst conventional wisdom says that PLS always converges in practice, there is no formal proof for path models with more than two blocks of manifest variables. This paper presents six cases of non-convergence of the PLS path modeling algorith...