metallo-β-lactamase (mbl) producing pseudomonas aeruginosa has been reported to be an important nosocomial infection. its intrinsic and acquired resistance to various antimicrobial agents and its ability to develop multidrug resistance imposes a serious therapeutic problem. different clinical samples were collected from public and private hospitals in baghdad city, iraq. bacterial identificatio...

Abstract Background Diarrhoea is a major cause of childhood disease in the developing countries. This experimental study investigated prevalence ESBL and MBL genes enteropathogenic strains Escherichia coli Salmonella spp. isolated from diarrheagenic children Awka, Nigeria. Methods Two hundred stool samples were collected diarrhea patients three paediatric hospitals within Awka metropolis, All E...

background and objectives: acinetobacter causes a wide variety of illness in debilitated and hospitalized patients. carbapenem resistance in acinetobacter is an emerging problem and is a cause of concern as many nosocomial infections with acinetobacter are resistant to most other antibiotics. the present study was aimed to study metallo-β-lactamase (mbl) production in acinetobacter species. mat...

BACKGROUND/PURPOSE To investigate the in vitro and in vivo activity of imipenem-colistin combination against multidrug-resistant Enterobacter cloacae infections in order to determine whether it should be explored further. METHODS The antimicrobial activity of colistin alone and in combination with imipenem was assessed versus an imipenem-susceptible isolate, E. cloacae GN1059, or an imipenem-...

Chemotherapy of tuberculosis caused by multiple-drug-resistant (MDR) strains is problematic because of choices limited to relatively inefficacious and toxic drugs. Some beta-lactam antibiotics are active against Mycobacterium tuberculosis in vitro. We investigated the efficacy of imipenem in a mouse model of tuberculosis and in humans with MDR tuberculosis. Mice infected with M. tuberculosis st...

incidence of imipenem-resistant acinetobacter baumannii in a general intensive care unit (icu)

We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.

Although imipenem has in vitro activity against Enterococcus faecalis and Food and Drug Administration-approved indications for treatment of infections caused by this microorganism, there are no NCCLS guidelines for susceptibility testing of imipenem versus enterococci. Therefore, the in vitro activities of penicillin, ampicillin, imipenem, and vancomycin against 201 blood isolates of E. faecal...

BACKGROUND Carbapenem-resistance is an extremely growing medical threat in antibacterial therapy as the incurable resistant strains easily develop a multi-resistance action to other potent antimicrobial agents. Nonetheless, the protective delivery of current antibiotics using nano-carriers opens a tremendous approach in the antimicrobial therapy, allowing the nano-formulated antibiotics to beat...