OBJECTIVES The effectiveness of evaluation of the severity of epidermal growth-factor receptor inhibitor (EGFRI)-associated dermatological toxicities remains a topic of debate. This study was designed to assess the correlation between quality of life (QoL) and severity of dermatological toxicity, evaluated using the National Cancer Institute's Common Terminology Criteria for Adverse Events (NCI...

Ontology design and maintenance require an expertise in both the domain of application and the ontology language. Realistic ontologies typically model different aspects of an application domain at various levels of granularity; prominent examples are the National Cancer Institute Ontology (NCI), which describes diseases, drugs, proteins, etc., and GALEN, which represents knowledge mainly about ...

AIM The aim of the study was to compare two different neurotoxicity scales in grading chemotherapy-induced neurotoxicity. PATIENTS AND METHODS The study sample consisted of 114 cancer patients who started chemotherapy with vinca alcaloids, platinum derivatives or taxanes. Neurotoxicity was evaluated with the National Cancer Institute-Common Toxicity Criteria (NCI-CTC) and oxaliplatin scales a...

The National Cancer Institute has developed the NCI Thesaurus, a biomedical vocabulary that provides consistent, unambiguous codes and definitions for concepts used in cancer research. It currently has about 34,000 concepts, in 20 hierarchies. A lexical component provides human usable definition and other information. Description logic is used to ensure complete, consistent and non-redundant de...

A rural Chinese province recently reported a nearly forty percent increase in H. Pylori bacterium infections after a 1994 National Cancer Institute (“NCI”) study was conducted in the region. The study began in 1988 after the NCI partnered with Chinese researchers to: (1) determine the prevalence of H. Pylori bacteria, the leading cause of stomach ulcers and a risk-raising factor for stomach can...

Dynamic functional integration of distinct neural systems plays a pivotal role in emotional experience. We introduce a novel approach for studying emotion-related changes in the interactions within and between networks using fMRI. It is based on continuous computation of a network cohesion index (NCI), which is sensitive to both strength and variability of signal correlations between pre-define...

We previously showed that functional N-methyl-D-aspartate (NMDA) receptors are expressed by human neuroblastoma cells. In this study we demonstrate functional NMDAR1 and NMDAR2 receptors are expressed by small-cell lung cancer (SCLC) classical cell lines NCI H146, NCI H345, and DMS 53, by variant cell line NCI H82, and by most SCLC tumors, and that these receptors are important for the growth o...

NCI-H295, a human adrenocarcinoma cell line, has been proposed as a model system to define the role of the renin-angiotensin system in the regulation of aldosterone production in humans. Because the precise cellular localization of the components of the renin-angiotensin system in human adrenal cortical cells remains unclear, we investigated their localization in this defined cell system. NCI-H...

Neurocognitive impairment (NCI) is frequently observed in patients infected with human immunodeficiency virus (HIV) and results from the compromise of subcortical brain structures by the virus. The manifestations of NCI range from asymptomatic impairment to dementia. In addition to cognitive impairment resulting from HIV infection, other factors such as depression are associated with the loss o...

The National Cancer Act of 1971 resulted in a threefold increase in appropriations for the National Cancer Institute (NCI) within a 4-year period. A major effect was the increase for the Grants Program from +93 million in fiscal year 1970 to more than +280 million in 1974. Grant programs, administered by the Division of Cancer Research Resources and Centers, account for more than 50% of the tot...