The apparent oral clearance (CL/F, mL/min) of busulfan was measured in 279 adolescent and adult patients. Significant (P <.05) determinants of CL/F by linear regression were: actual body weight (BW; r2 = 0.300), body surface area (BSA; r2 = 0.277), adjusted ideal body weight (AIBW; r2 = 0.265), and ideal body weight (IBW; r2 = 0.173); whereas body mass index (BMI), height, age, gender, and dise...

Novel p-tolylimido rhenium(v) complexes trans-(Cl,Cl)-[Re(p-NC6H4CH3)Cl2(pyz-2-COO)(PPh3)]·MeCN (1), trans-(Cl,Cl)-[Re(p-NC6H4CH3)Cl2(pyz-2-COO)(PPh3)] (2), trans-(Br,Br)-[Re(p-NC6H4CH3)Br2(pyz-2-COO)(PPh3)] (3), cis-(Cl,Cl)-[Re(p-NC6H4CH3)Cl2(ind-3-COO)(PPh3)]·2MeOH (4), 2[Re(p-NC6H4CH3)Cl2(ind-3-COO)(PPh3)]·MeCN (5), 2[Re(p-NC6H4CH3)Br2(ind-3-COO)(PPh3)]·MeOH (6) and 2[Re(p-NC6H4CH3)Br2(ind-3...

The luminescent and recombination properties of V-pit defects in p-GaN(Mg) grown by metalorganic chemical vapor deposition (MOCVD) were studied scanning electron microscopy (SEM) the secondary electron, cathodoluminescence (CL), beam induced current (EBIC) modes, combined with CL spectra measurements EBIC collection efficiency measurements. Similar studies performed on low-dislocation-density f...

ion has, however, been compromised by the aliasing, and accidental side-effects can leak into the calling contexts, exposing unnecessary implementation details of the procedure. In the early days of programming language design, before programs were particularly sophisticated, the ability to write simple abstractions such as swap was considered valuable (since it is used, for instance, in the im...

The gut contents of larval mosquitoes are alkalinized by the anterior midgut and reacidified by the posterior midgut. In the present study the cellular mechanisms of reacidification were studied in isolated, perfused posterior midgut by measuring the transepithelial voltage (V(te)) and the rate of acid secretion as indicated by the color change of m-cresol purple during intervals of perfusion s...

A density functional theory study of the magnetic couplings in Sr2V3O9 type magnetic oxides suggests that whereas the intrachain coupling is always weakly ferromagnetic, the interchain coupling may be antiferromagnetic or even weakly ferromagnetic depending on the nature of the central tetrahedral atom (As/V) cations, and, to a lesser extent, structural details.

Mutations in the bestrophin-1 (Best1) gene are linked to several kinds of macular degeneration in both humans and dogs. Although bestrophins have been shown clearly to be Cl(-) ion channels, it is controversial whether Cl(-) channel dysfunction can explain the diseases. It has been suggested that bestrophins are multifunctional proteins: they may regulate voltage-gated Ca(2+) channels in additi...

The pharmacokinetics of cefepime following administration of a single 2-g dose were evaluated for 12 adult patients with thermal burn injury and suspected or documented infection. Serial blood and urine samples for cefepime concentration determination were obtained for 24 h following drug administration. Serum and urine cefepime concentrations were determined by high-performance liquid chromato...

Vibrio cholerae O1 biotype El Tor (ET), the cause of the current 7th pandemic, has recently been replaced in Asia and Africa by an altered ET biotype possessing cholera toxin (CTX) of the classical (CL) biotype that originally caused the first six pandemics before becoming extinct in the 1980s. Until recently, the ET prototype was the biotype circulating in Peru; a detailed understanding of the...