AMPK is a sensor of cellular energy status and a promising target for drugs aimed at metabolic disorders. We have studied the selectivity and mechanism of a recently described activator, C2, and its cell-permeable prodrug, C13. C2 was a potent allosteric activator of α1-complexes that, like AMP, also protected against Thr172 dephosphorylation. Compared with AMP, C2 caused only partial allosteri...

Resolution of acute and chronic viral infections requires activation of innate cells to initiate and maintain adaptive immune responses. Here we report that infection with acute Armstrong (ARM) or chronic Clone 13 (C13) strains of lymphocytic choriomeningitis virus (LCMV) led to two distinct phases of innate immune response. During the first 72 hr of infection, dendritic cells upregulated activ...

Dipole sonic log data recorded in a vertical pilot well and the associated production well are analyzed over a 200 × 1100-ft section of a North American gas shale formation. The combination of these two wells enables angular sampling in the vertical direction and over a range of inclination angles from 54° to 90°. Dipole sonic logs from these wells show that the formation’s average properties a...

The synthesis and characterization of cadmium and mercury complexes of selenocyanate of the type [(L)M(SeCN)2] are described, where L is L-Histidine (His) or L-Glycine (Gly) and M is Cd(2+) or Hg(2+). These complexes are obtained by the reaction of 1 equivalent of respective amino acids with metal diselenocyanate precursor in a mixture of solvents (methanol : water = 1 : 1). These synthesized c...

A 2.4-Å-resolution X-ray crystal structure of the carrier-protein-independent halogenase WelO5 in complex with its welwitindolinone precursor substrate, 12-epi-fischerindole U, reveals that the C13 chlorination target is proximal to the anticipated site of the oxo group in a presumptive cis-halo-oxo-iron(IV) (haloferryl) intermediate. Prior study of related halogenases forecasts substrate hydro...

In this study, the use of linear alkylbenzenes (LABs) was employed to pinpoint sources human activity that cause detrimental impacts on coastal environment and river ecosystems. LABs were detected using GC–MS in sediment samples assembled from Kim River (KKR) Port Dickson coast (PDC). To assess significance variations distribution concentrations across sampling sites, study utilized several sta...

Background : Recently, Bijker et al. [Phys. Rev. Lett. 122, 162501 (2019)] explained the rotation-vibration spectrum of 13C by assuming triangular nuclear shape with D'3h symmetry. Purpose The purpose this work is to test and symmetry based on a microscopic model without assumption shape. Method We have applied real-time evolution method 13C. By using equation-of-motion clusters, describes 3alp...

Ovarian cancer is one of the major causes of death in women. Parabens are a class of chemicals widely used as preservatives in cosmetic and pharmaceutical products, they mimic estrogens, which are known to play a role in the development of different cancers in women. The Aim of this study was to investigate the proliferative effects of Methyl Paraben (MP) and Propyl Paraben (PP) on human ovaria...