BACKGROUND AND STUDY AIMS Although peroral endoscopic myotomy (POEM) is being performed more frequently, the learning curve for gastroenterologists performing the procedure has not been well studied. The aims of this study were to define the learning curve for POEM and determine which preoperative and intraoperative factors predict the time that will be taken to complete the procedure and its d...

We have used seismic signals recorded at regional and teleseismic distances to determine precise locations of 19 underground nuclear explosions (13 in vertical shafts, and 6 in horizontal tunnels) carried out between October 1976 and July 1996 at the Lop Nor test site in the southern Xinjiang province of China. In addition to firstand later-arriving phase-pick data from the International Seismo...

BACKGROUND Organism's lipid peroxidation is one of the most often examined and known physiological process evoked by free radicals. It concerns oxidation reaction of unsaturated fatty acid and/or other lipids leading to lipid oxidation products (LOP), which as a result of further changes generate among others the malondialdehyde molecules. The aim of the work was an estimation if raw or cooked ...

A simple three-step procedure for the large scale purification of DNA ligase has been developed. THe source of enzyme is a strain of Escherichia coli with a hybrid lambda prophage constructed in vitro that bears the ligase overproducing gene lop 11 lig+ (Panasenko, S., Cameron, J., Davis, R. W., and Lehman, I. R. (1977) Science 196, 188-189). The procedure yields homogeneous enzyme in approxima...

The Linear Ordering Problem(LOP), which is a well-known NP-hard problem, has numerous applications in various fields. Using this problem as an example, we illustrate a general procedure of designing a hybrid genetic algorithm, which includes the selection of crossover/mutation operators, accelerating the local search module and tuning the parameters. Experimental results show that our hybrid ge...

Research funders can play an important role in supporting the integration of marine science into policy and practice to enable evidence-informed decision-making. However, date, there is a paucity guidance available help research understand specific actions they take support knowledge exchange among researchers that fund relevant stakeholders, particularly within contexts. This Brief Report aims...

We consider the following ways of extending a family of languages K to an “enriched ” family X(K): (i) hyper-algebraic extension (X = H) based on iterated parallel substitution, (ii) algebraic extension (X = A) obtained by nested iterated substitution, (iii) rational extension (X = R) achieved by not self-embedding nested iterated substitution, and (iv) a few subrational extensions (X = M,C, S,...

Globalization is a complex phenomenon, best represented by general framework in which all financial markets and some goods adjust quickly, while for the other prices vary across countries. We consider two-period model. In first period, agents consume, buy sell assets to diversify their portfolios. second they spend endowments gains purchase consumption goods. define concept equilibrium*, total ...