نتایج جستجو برای: تصویر irs

تعداد نتایج: 22679  

Journal: :Theor. Comput. Sci. 2007
Rui Wang Francis C. M. Lau Yan Yan Liu

k-Interval Routing Scheme (k-IRS) is a compact routing method that allows up to k interval labels to be assigned to an arc; and global k-IRS allows not more than a total of k interval labels in the whole network. A fundamental problem is to characterize the networks that admit k-IRS (or global k-IRS). Many of the problems related to single-shortest-path k-IRS have already been shown to be NP-co...

Journal: :Diabetes 2001
S A El Mkadem C Lautier F Macari N Molinari P Lefèbvre E Renard J C Gris G Cros J P Daurès J Bringer M F White F Grigorescu

To assess the role of insulin receptor, insulin receptor substrate (IRS)-1, and IRS-2 genes in insulin resistance, we explored the genomic DNA in women with polycystic ovary syndrome (PCOS) and a variable degree (mean +/- SE) of insulin resistance (homeostasis model assessment index for insulin resistance [HOMA(IR)] 3.2 +/- 0.6, n = 53; control subjects 1.56 +/- 0.34, n = 102) using direct sequ...

Journal: :Endocrinology 1993
M G Myers X J Sun B Cheatham B R Jachna E M Glasheen J M Backer M F White

IRS-1 is a unique cytosolic protein that becomes tyrosine phosphorylated during insulin stimulation of intact cells and immediately associates with the phosphatidylinositol 3'-kinase (PtdIns 3'-kinase). The insulin-like growth factor-I (IGF-I) receptor also mediated the tyrosine phosphorylation of IRS-1 and increased the amount of PtdIns 3'-kinase activity bound to IRS-1 in Chinese hamster ovar...

Journal: :Endocrinology 2007
Moulun Luo Paul Langlais Zhengping Yi Natalie Lefort Elena A De Filippis Hyonson Hwang Christine Y Christ-Roberts Lawrence J Mandarino

The function of insulin receptor substrate-1 (IRS-1) is regulated by both tyrosine and serine/threonine phosphorylation. Phosphorylation of some serine/threonine residues in IRS-1 dampens insulin signaling, whereas phosphorylation of other serine/threonine residues enhances insulin signaling. Phosphorylation of human IRS-1 at Ser(629) was increased by insulin in Chinese hamster ovary cells expr...

2011
Xue Song Stacey R Long Beth Barber Cheryl A Kassed Marcus Healey Clare Jones Zhongyun Zhao

OBJECTIVE The objective of this systematic review is to summarize the literature to date on the rates of infusion reactions (IR) associated with chemotherapies and monoclonal antibody (mAb) drug therapies used for the treatment of metastatic colorectal cancer (mCRC) and the associated clinical and economic impact. METHODS This study searched Medline, Medline (R) In-Process, Embase and Cochran...

Journal: :Cell 2012
Takashi Kadowaki Naoto Kubota Kohjiro Ueki Toshimasa Yamauchi

See online version for legend and references. systemic IR Apparently normal intrauterine growth and development, severe hyperglycemia and hyperke-tonemia, perinatal death as the result of diabetic ketoacidosis within 48–72 hours IRS-1 Retarded embryonal and postnatal growth, insulin resistance, normal fasting glycemia and normal or mild glucose intolerance, hyperinsulinemia IRS-2 Insulin resist...

Journal: :IEEE Transactions on Wireless Communications 2023

The analysis and optimization of single intelligent reflecting surface (IRS)-assisted systems have been extensively studied, whereas little is known regarding multiple-IRS-assisted systems. This paper investigates the a double-IRS cooperatively assisted downlink system (D-IRS-C), where multi-antenna base station (BS) serves single-antenna user with help two multi-element IRSs, connected by an i...

Journal: :European journal of endocrinology 1998
A Shalev

The pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) includes the development of insulin resistance and, at a later stage, impairment of b-cell response. In the past few years, different elements, including the proto-oncogene, Shc, and the insulin receptor substrate (IRS) proteins, have been found to have important roles in the insulin signaling network. Whithers et al. (1) have ...

2016
Farshad Hakimpour John Domingue Enrico Motta Liliana Cabral Yuangui Lei

IRS-III is the first WSMO compliant system for supporting the Semantic Web Services technologies and it is based on the IRS-II [3]. This paper presents how we integrated the OWL-S [5] service description ontology to IRS-III. We describe how the underlying model of IRS-III supports OWL-S.

Journal: :Molecular cell 2012
Sung Jin Kim Michael A DeStefano Won Jun Oh Chang-chih Wu Nicole M Vega-Cotto Monica Finlan Dou Liu Bing Su Estela Jacinto

The mammalian target of rapamycin (mTOR) integrates signals from nutrients and insulin via two distinct complexes, mTORC1 and mTORC2. Disruption of mTORC2 impairs the insulin-induced activation of Akt, an mTORC2 substrate. Here, we found that mTORC2 can also regulate insulin signaling at the level of insulin receptor substrate-1 (IRS-1). Despite phosphorylation at the mTORC1-mediated serine sit...

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