Infections with Streptococcus pyogenes exhibit a wide spectrum of infections ranging from mild pharyngitis to severe Streptococcal toxic shock syndrome (STSS). The M1 serotype of Streptococcus pyogenes is most commonly associated with STSS. In the present study, we hypothesized that Rac1 signaling might regulate M1 protein-induced lung injury. We studied the effect of a Rac1 inhibitor (NSC23766...

Using 24 hours in vitro cultures of rumen microorganisms, this study investigates the effect of buffering capacity of 2 inorganic compounds (M1=119.43 and M2=116.50 meq/L) on the in vitro rumen acidogenic value (AV), medium pH, dry matter disappearance (INVDMD) and methane emission of lactating dairy cow diets containing various forage to concentrate ratios as 40:60 (FC40:60) and 30:70 (FC30:70...

Background & Aims: Aflatoxin M1 is one of the most important toxins present in milk and the product of aflatoxin B1 metabolism in liver microsomes. The aim of this project was to study the aflatoxin M1 adsorption ability of polystyrene-hydroxyapatite nanocomposite. Methods: First, the probability of aflatoxin M1 adsorption by the nanocomposite was evaluated using the HyperChem simulation softwa...

Background & objectives: Aflatoxins are secondary metabolites of fungi and one of the most important types of mycotoxins identified as a carcinogen for humans. The aim of this study was to determine the level of aflatoxin M1 in milk production of dairy factories in east Azerbaijan province by high performance liquid chromatography (HPLC). Methods: In this study, 45 samples of pasteurized milk ...

An international collaborative study involving 14 collaborators from 5 different countries was conducted to test a rapid liquid chromatographic (LC) method for detecting aflatoxins M1 and M2 in fluid milk. Each collaborator prepared artificially contaminated milk samples (0.078-1.31 ng M1/mL and 0.030-0.13 ng M2/mL) by adding solutions containing various concentrations of aflatoxins M1 and M2 t...

Most neuroimaging research in stroke rehabilitation mainly focuses on the neural mechanisms underlying the natural history of post-stroke recovery. However, connectivity mapping from resting-state fMRI is well suited for different neurological conditions and provides a promising method to explore plastic changes for treatment-induced recovery from stroke. We examined the changes in resting-stat...

glutathione s-transferases (gsts) are encoded by a superfamily of genes and play a role in the detoxification of potential carcinogens. the human gsts are divided into four classes: alpha, mu, pi and theta. previous studies indicated that the absence of the glutathione s-transferase m1 (gstm1) protein correlated with an increased risk of developing some types of cancers. association between spe...

background: aflatoxin m 1 (afm 1 ) is the metabolite of aflatoxin b1 (afb 1 ) and is found in milk when lactating animals are fed with contaminated feedstuff.  the presence of afm 1 in milk, pose a major risk for humans especially kids as it can have immunosuppressive, mutagenic, teratogenic and carcinogenic effects. the present study is aimed to investigate the oc­currence of afm 1 in subsidiz...

background: the presence of aflatoxin m1 (afm1) andantibiotic residues in milk and milk products is a public healthconcern. milk and milk powder have the potential forintroducing afm1 and antibiotic into human diet. in recentyears, milk powder has been used on a large scale in dairyfactories. consequently, antibiotic residues and aflatoxincontamination control in these products has gained impor...