In yeast, DNA polymerase zeta (Rev3 and Rev7) and Rev1, involved in the error-prone translesion synthesis during replication of nuclear DNA, localize also in mitochondria. We show that overexpression of Rev3 reduced the mtDNA extended mutability caused by a subclass of pathological mutations in Mip1, the yeast mitochondrial DNA polymerase orthologous to human Pol gamma. This beneficial effect w...

Also known as.... Translesion synthesis polymerases. There are two of them in Escherichia coli, polymerases IV and V, and five in human cells, polymerases ζ, η, ι, κ and Rev1 (so a knowledge of the Greek alphabet is essential when discussing them). Except for polymerase ζ, they fall into a new DNA polymerase family, designated the Y-family. Depending on the lesion, polymerase and context, they ...