Most of the estimated 1000 or so chloroplast proteins are synthesized as cytosolic preproteins with N-terminal cleavable targeting sequences (transit peptide). Translocon complexes at the outer (Toc) and inner chloroplast envelope membrane (Tic) concertedly facilitate post-translational import of preproteins into the chloroplast. Three components, the Toc34 and Toc159 GTPases together with the ...

We examined whether multidrug resistant (MDR) canine lymphoma increases gene expression for platelet-derived growth factor receptor α (PDGFRα), vascular endothelial growth factor receptor 2 (VEGFR2), and c-KIT, and whether toceranib phosphate (TOC) has potential as a treatment for MDR canine lymphoma. The clinical data showed that PDGFRα expression was higher in canine subjects with MDR T-cell ...

It's intended to give an approximation to the Theory of Constraints (TOC), to achieve that goal we explain the conceptual bases, the thinking process, the flow management and later on we will focus on its application into production, also known as DBR (Drum-Buffer-Rope). A usual critic in the academic environment is that TOC techniques produce results that are feasible but not always optimal. A...

Since the development bloom in unconventional reservoirs in North America, total organic carbon (TOC) has become a more essential parameter, as the indicator of the efficiency of these reservoirs. In this paper, by using conventional well logs and NMR log data, the TOC content of an unconventional reservoir in West Africa is estimated. Passy’s, Issler’s, and Schmoker’s methods were used as indi...

Theories of change (ToCs) describe how interventions can bring about long-term outcomes through a logical sequence of intermediate outcomes and have been used to design and measure the impact of public health programmes in several countries. In recognition of their capacity to provide a framework for monitoring and evaluation, they are being increasingly employed in the development sector. The ...

The molecular basis of the positive association between apoE4 genotype and CVD remains unclear. There is direct in vitro evidence indicating that apoE4 is a poorer antioxidant relative to the apoE3 isoform, with some indirect in vivo evidence also available. Therefore it was hypothesised that apoE4 carriers may benefit from alpha-tocopherol (alpha-Toc) supplementation. Targeted replacement mice...

A significant challenge in systems engineering and acquisition is to justify investments in system flexibility as opposed to buying more features or copies of a less-flexible systems. The Total Ownership Cost (TOC) has the advantages of having clear cause-effect relationships that are easy to understand and reason about. We present two TOC models for valuing flexibility that have been calibrate...

(UV) light-induced skin damage. On the other hand, overexposure to UV radiation can lead to a pathological increase in melanin production. Epidermal hyper-pigmentation results from the increased activity of melanogenic enzymes such as tyrosinase. Tyrosinase oxidizes the conversion of L-tyrosine to 3,4-dihydroxyphenylalanine (DOPA) and DOPA to DOPA quinone, which are the first two rate limiting ...